Effect of dopamine2 blockade on renal function under varied sodium intake

• Published in: The journal of clinical endocrinology and metabolism Vol. 78; no. 5; p. 1079
• Main Authors: Bughi, S, Jost-Vu, E, Antonipillai, I, Nadler, J, Horton, R
• Format: Journal Article
• Language: English
• Published: United States 01.05.1994
• Subjects: Adult; Domperidone - pharmacology; Dopamine - pharmacology; Dopamine D2 Receptor Antagonists; Epoprostenol - urine; Humans; Kidney - physiology; Male; Middle Aged; Receptors, Dopamine D2 - physiology; Renin - blood; Sodium, Dietary - administration & dosage

This study explored the role of the dopamine-2 receptor (DA2) in the control of renal blood flow (RBF) and the influence of variations in sodium intake. These relationships have not been previously defined in man. Seven normotensive male subjects underwent a low dose dopamine (DA) infusion (1 microg...