The differential antibacterial and gastrointestinal effects of erythromycin and its chiral isolates

• Published in: American journal of therapeutics Vol. 13; no. 1; p. 48
• Main Authors: Cvetanovic, Ivana, Ranade, Vasant, Lin, Congrong, Somberg, John
• Format: Journal Article
• Language: English
• Published: United States 01.01.2006
• Subjects: Action Potentials - drug effects; Animals; Anti-Bacterial Agents - adverse effects; Anti-Bacterial Agents - chemistry; Anti-Bacterial Agents - pharmacology; Colon - drug effects; Colon - physiology; Enterococcus faecalis - drug effects; Erythromycin - adverse effects; Erythromycin - chemistry; Erythromycin - pharmacology; In Vitro Techniques; Male; Microbial Sensitivity Tests; Muscle Contraction - drug effects; Muscle, Smooth - drug effects; Muscle, Smooth - physiology; Rats; Rats, Sprague-Dawley; Stereoisomerism

The use of erythromycin has been limited by the gastrointestinal side effect properties, which include abdominal distress and diarrhea. To evaluate the possibility of reducing the toxicity of erythromycin, studies were undertaken to separate erythromycin into chiral isolates and then to test the act...