A carboxymethyl cellulose enhanced F127 hydrogel with anti-inflammation and peritoneum regeneration activities for preventing peritoneal adhesion

• Published in: International journal of biological macromolecules Vol. 320; no. Pt 4; p. 146054
• Main Authors: Hou, Chuanyu, Zhong, Zhensheng, Long, Naibin, Cao, Yaoling, Yang, Zhihao, Zhai, Zhen, He, Jun, Wang, Jiankang, Lyu, Jifu, Wang, Juan, Qian, Haisheng, Zhou, Jinhua, Tang, Qinqing
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.08.2025
• Subjects: Animals; Anti-inflammation; Anti-Inflammatory Agents - chemistry; Anti-Inflammatory Agents - pharmacology; Carboxymethyl cellulose; Carboxymethylcellulose Sodium - chemistry; Carboxymethylcellulose Sodium - pharmacology; Humans; Hydrogels - chemistry; Hydrogels - pharmacology; Male; Peritoneum - drug effects; Peritoneum - pathology; Peritoneum - physiology; Peritoneum regeneration; Pluronic F127; Poloxamer - chemistry; Poloxamer - pharmacology; Postoperative peritoneal adhesion; Rats; Rats, Sprague-Dawley; Regeneration - drug effects; Tissue Adhesions - pathology; Tissue Adhesions - prevention & control; Transforming Growth Factor beta1 - metabolism; Wound Healing - drug effects; Carboxymethyl cellulose; Pluronic F127; Peritoneum regeneration; Anti-inflammation; Postoperative peritoneal adhesion

Postoperative peritoneal adhesion (PPA) is a common and severe postoperative complication that does not require satisfactory precautions by surgeons. By combining Pluronic F127 and carboxymethyl cellulose (CMC), we developed an F127- CMC hydrogel (designated as FC hydrogel), and characterized and te...