Correlation between salivary biomarkers and plaque-induced gingivitis exacerbated by pregnancy

• Published in: Journal of oral research Vol. 11; no. 3; pp. 1 - 12
• Main Authors: Aragon-Martinez, Othoniel, Loredo-Escobar, Karen, Cepeda-Bravo, Juan, Martinez-Morales, Flavio, Gonzalez-Rivera, Maria, Aranda Romo, Saray
• Format: Journal Article
• Language: English
• Published: Universidad de Concepción 30.06.2022
• Subjects: Antioxidantes; antioxidants; Biomarcadores; biomarkers; Embarazo; Gingivitis inducida por placa; induced gingivitis; plaque; plaque-induced gingivitis; Polifenoles; polyphenols; pregnancy; Saliva
• ISSN: 0719-2460; 0719-2479; 0719-2479
• DOI: 10.17126/joralres.2022.032

Objetive: To evaluate the correlation between salivary biomarkers (the salivary antioxidant ability, salivary level of polyphenols, and other antioxidants) with plaque-induced gingivitis exacerbated by pregnancy in pregnant and nonpregnant women. Material and Methods: For this observational study, medical records, dental examinations, and analyses of saliva samples were carried out in pregnant and nonpregnant women. A p-value of <0.05 was considered significant. Results: The pregnant women (n =17) exhibited a lower antioxidant capacity (p-value=0.0041), higher levels of polyphenols, gingival index, bleeding on probing, and subjects consuming mineral-enriched products (p-value from <0.0001 to 0.0466), and unchanged levels of phosphotungstic acid reactive substances, proteins, oral hygienic habits, plaque index and probing depth (p-value from 0.0683 to 0.8358), in comparison with the nonpregnant women (n=9). Also, a positive correlation between the gingival index and salivary polyphenol content was observed (r-value = 0.4087, p-value = 0.0202). Conclusion: The salivary polyphenols correlate with plaque-induced gingivitis exacerbated by pregnancy, suggesting a deficiency of salivary antioxidant protection.