The Utility of Screening for Coccidioidomycosis in Recipients of Inhibitors of Tumor Necrosis Factor α

• Published in: Clinical infectious diseases Vol. 68; no. 6; pp. 1024 - 1030
• Main Authors: Choi, Kristal, Deval, Neha, Vyas, Anuj, Moran, Conor, Cha, Stephen S, Mertz, Lester E, Pasha, Shabana F, Yiannias, James A, Blair, Janis E
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 05.03.2019
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Biopsy; Coccidioides; Coccidioidomycosis - diagnosis; Coccidioidomycosis - epidemiology; Coccidioidomycosis - etiology; Disease Management; Female; Humans; Male; Mass Screening - methods; Middle Aged; Patient Outcome Assessment; Radiography; Serologic Tests - methods; Symptom Assessment; Tumor Necrosis Factor Inhibitors - adverse effects; Tumor Necrosis Factor Inhibitors - therapeutic use; Young Adult; biologic drugs; TNFα inhibitors; coccidioidomycosis

Abstract Background Tumor necrosis factor α inhibitors (TNFi) are commonly used to treat immune-mediated disorders, but they are associated with an increased risk of mycobacterial and fungal infections. We compared the outcomes of TNFi recipients screened for asymptomatic coccidioidomycosis with tho...