Insights into the Inhibitory Mechanisms of the Regulatory Protein IIAGlc on Melibiose Permease Activity

• Published in: The Journal of biological chemistry Vol. 289; no. 47; pp. 33012 - 33019
• Main Authors: Hariharan, Parameswaran, Guan, Lan
• Format: Journal Article
• Language: English
• Published: 9650 Rockville Pike, Bethesda, MD 20814, U.S.A Elsevier Inc 21.11.2014; American Society for Biochemistry and Molecular Biology
• Subjects: Carbohydrate Metabolism; Energetics; IIAGlc Binding; Isothermal Titration Calorimetry (ITC); Melibiose Permease; Molecular Biophysics; Protein-Protein Interaction; PTS; Sugar Binding; Thermodynamics; Energetics; Thermodynamics; Melibiose Permease; IIAGlc Binding; Protein-Protein Interaction; Carbohydrate Metabolism; Isothermal Titration Calorimetry (ITC); Sugar Binding; PTS

The phosphotransfer protein IIAGlc of the bacterial phosphoenolpyruvate:carbohydrate phosphotransferase system plays a key role in the regulation of carbohydrate metabolism. Melibiose permease (MelB) is one among several permeases subject to IIAGlc regulation. The regulatory mechanisms are poorly un...