ATP-induced apoptosis involves a Ca2+-independent phospholipase A2 and 5-lipoxygenase in macrophages

• Published in: Prostaglandins & other lipid mediators Vol. 88; no. 1-2; pp. 51 - 61
• Main Authors: Costa-Junior, Helio Miranda, Mendes, Anderson Nogueira, Davis, Gustavo Henrique Nolasco Grimmer, da Cruz, Cristiane Monteiro, Ventura, Ana Lúcia Marques, Serezani, Carlos Henrique, Faccioli, Lucia Helena, Nomizo, Auro, Freire-de-Lima, Célio G, Bisaggio, Rodrigo da Cunha, Persechini, Pedro Muanis
• Format: Journal Article
• Language: English
• Published: United States 01.01.2009
• Subjects: Adenosine Triphosphate - metabolism; Adenosine Triphosphate - pharmacology; Animals; Apoptosis; Arachidonate 5-Lipoxygenase - metabolism; Calcium - metabolism; Cell Death; Macrophages - enzymology; Mice; Mice, Inbred C57BL; Mitogen-Activated Protein Kinases - metabolism; Phospholipases A2, Calcium-Independent - metabolism

Macrophages express P2X(7) and other nucleotide (P2) receptors, and display the phenomena of extracellular ATP (ATP(e))-induced P2X(7)-dependent membrane permeabilization and cell death by apoptosis and necrosis. P2X(7) receptors also cooperate with toll-like receptors (TLRs) to induce inflammasome...