LncRNA LINC01278 Regulates the Prognosis and Related Mechanisms of Gastric Cancer by Targeting miR-129-5p

Gastric cancer, a prevalent malady within the digestive tract, has a complex pathological mechanism and numerous patients. The regulation of gastric cancer process by long non-coding RNA (lncRNA) presented new prospects for the study of its molecular mechanism and the treatment of patients. The abno...

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Published inJournal of environmental pathology, toxicology and oncology Vol. 43; no. 4; p. 43
Main Authors Wang, Zhenhua, Liu, Liyan, Li, Zhengliang, Liu, Xiaojing, Wang, Jundong, Wang, Jiaxi, Jiang, Guoxiang, Yu, Haizhou
Format Journal Article
LanguageEnglish
Published United States 2024
Subjects
Cell Line, Tumor
Female
Gene Expression Regulation, Neoplastic
Humans
Male
MicroRNAs - genetics
Middle Aged
Prognosis
RNA, Long Noncoding - genetics
Stomach Neoplasms - genetics
Stomach Neoplasms - pathology
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Summary:Gastric cancer, a prevalent malady within the digestive tract, has a complex pathological mechanism and numerous patients. The regulation of gastric cancer process by long non-coding RNA (lncRNA) presented new prospects for the study of its molecular mechanism and the treatment of patients. The abnormal expressed genes in gastric cancer were screened by GSE193109 dataset. The correlation between LINC01278 and the likelihood of survival in patients suffering from gastric cancer was investigated by Kaplan-Meier survival curve and multivariate Cox analysis. LINC01278 in gastric cancer tissue samples and cells was verified via RT-qPCR. The cell counting kit-8 (CCK-8) and transwell assay were selected to detect the growth activity of gastric cancer cells. The association between LINC01278 and miR-129-5p was validated through luciferase reporter assay and RNA-binding protein immunoprecipitation (RIP) assay. Correlation analysis of clinical features revealed an association between LINC01278 and the prognosis in gastric cancer patients. LINC01278 was actively expressed in gastric cancer, which exerts a tumor-promoting effect. Silencing LINC01278 suppressed the biological function of tumor cells through spongiform miR-129-5p. LINC01278 has the potential to serve as a novel biomarker, offering new avenues of research for the prognosis and treatment of gastric cancer.
ISSN:2162-6537
DOI:10.1615/JEnvironPatholToxicolOncol.2024053208