Presence of two isoforms of Na, K-ATPase with different pharmacological and immunological properties in the rat kidney

• Published in: Pflügers Archiv Vol. 430; no. 2; p. 205
• Main Authors: Féraille, E, Barlet-Bas, C, Cheval, L, Rousselot, M, Carranza, M L, Dreher, D, Arystarkhova, E, Doucet, A, Favre, H
• Format: Journal Article
• Language: English
• Published: Germany 01.06.1995
• Subjects: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Specificity; Isoenzymes - analysis; Isoenzymes - antagonists & inhibitors; Isoenzymes - chemistry; Kidney - enzymology; Kidney Tubules - enzymology; Kidney Tubules, Collecting - enzymology; Kidney Tubules, Proximal - enzymology; Male; Molecular Sequence Data; Nephrons - enzymology; Ouabain - pharmacology; Rats; Rats, Wistar; Sodium-Potassium-Exchanging ATPase - analysis; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors; Sodium-Potassium-Exchanging ATPase - chemistry

Previous studies have demonstrated the presence of two populations of Na,K-ATPase with distinct kinetic, pharmacological and immunological characteristics along the rabbit nephron, indicating that the proximal segments of the nephron express exclusively the alpha 1 isoform of the catalytic subunit,...