Meglumine catalyzed expeditious four-component domino protocol for synthesis of pyrazolopyranopyrimidines in aqueous medium

A facile and highly efficient protocol for the one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid has been developed using meglumine as an inexpensive, biodegradable and reusable catalyst. This methodology provides a mild and fast route...

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Bibliographic Details
Published inRSC advances Vol. 4; no. 93; pp. 51580 - 51588
Main Authors Li, Xiao-Tang, Zhao, Ai-Dong, Mo, Li-Ping, Zhang, Zhan-Hui
Format Journal Article
LanguageEnglish
Published 01.01.2014
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Summary:A facile and highly efficient protocol for the one-pot, four-component reaction of ethyl acetoacetate, hydrazine hydrate, aromatic aldehydes and barbituric acid has been developed using meglumine as an inexpensive, biodegradable and reusable catalyst. This methodology provides a mild and fast route to structurally diverse tricyclic fused pyrazolopyranopyrimidines in good to excellent yields. Simplicity, room temperature reaction conditions, a green solvent, an easy work-up process, inexpensive price and reusability of the catalyst are the main advantages of this method.
ISSN:2046-2069
2046-2069
DOI:10.1039/C4RA08689A