Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type

• Published in: Heterocycles Vol. 45; no. 10; pp. 1967 - 1978
• Main Authors: vandenEynde, JJ, Audiart, N, Canonne, Michel, S, VanHaverbeke, Y, Kappe, CO
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier 1997
• Subjects: Chemistry; Chemistry, Organic; Physical Sciences; Science & Technology; BLOCKERS; OXIDATION; ANTIHYPERTENSIVE AGENTS; NITRATE; HANTZSCH 1,4-DIHYDROPYRIDINES; DIHYDROPYRIDINES; TAUTOMERISM; ACID-ESTERS; PYRIDINIUM CHLOROCHROMATE; POTENT MIMICS

A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which...