Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type
A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which...
Saved in:
Published in | Heterocycles Vol. 45; no. 10; pp. 1967 - 1978 |
---|---|
Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
1997
|
Subjects | |
Online Access | Get more information |
Cover
Loading…
Abstract | A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain. |
---|---|
AbstractList | A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain. |
Author | vandenEynde, JJ VanHaverbeke, Y Audiart, N Michel, S Kappe, CO Canonne |
Author_xml | – sequence: 1 givenname: JJ surname: vandenEynde fullname: vandenEynde, JJ – sequence: 2 givenname: N surname: Audiart fullname: Audiart, N – sequence: 3 surname: Canonne fullname: Canonne – sequence: 4 givenname: S surname: Michel fullname: Michel, S – sequence: 5 givenname: Y surname: VanHaverbeke fullname: VanHaverbeke, Y – sequence: 6 givenname: CO orcidid: 0000-0003-2983-6007 surname: Kappe fullname: Kappe, CO |
BookMark | eNqNkM1OAyEUhVnUxLa68gXYm1FgOgWWzcRqkyYu1IWrhsIlxczABJiY0ZcXfx7AxcldnJzv5pwFmvngAaErSm5qKfitDn0lecVlTWdoTmrRVM2Krs7RIqU3QoggQszR59Pk8wmSS1h5g1UMvcruoyh4HCw27jSZGIYput4Z5yHhlOOo8xhV1004QqcyGJwD1qrTbuyxPinvocN9MGMxQ0zfoPIEe2fBuKFQqjwNcIHOrOoSXP7dJXrZ3j23D9X-8X7XbvaVZjXNlaCayaNcCasVNLaoBsbWR8UlMVpa2oCxRlngVCpTC96YYrG1IIpywiRbIvHLfYdjsEk78BoOQ2mk4nTYUCn565aKsgmh69bln_JtGH0u0ev_R9kXDQB4sw |
CitedBy_id | crossref_primary_10_1016_j_tet_2011_05_105 crossref_primary_10_1021_jo801956w crossref_primary_10_3184_174751912X13518654161237 crossref_primary_10_1007_s00706_011_0573_8 crossref_primary_10_1007_s10593_014_1428_0 crossref_primary_10_1071_CH07432 crossref_primary_10_1039_C9GC02005E crossref_primary_10_1002_jhet_5570380616 crossref_primary_10_1002_slct_202201630 crossref_primary_10_1016_S1350_4177_03_00092_0 crossref_primary_10_1021_jo050675q crossref_primary_10_1134_S1070428017060094 crossref_primary_10_1007_s13738_013_0221_9 crossref_primary_10_1016_j_tet_2011_02_046 crossref_primary_10_1016_j_tet_2006_07_063 crossref_primary_10_1134_S1070363216110062 crossref_primary_10_3987_COM_03_9837 crossref_primary_10_1016_j_tetlet_2012_08_017 crossref_primary_10_1016_S0040_4039_02_02612_6 crossref_primary_10_1134_S1070428016050195 crossref_primary_10_1021_jp2014435 crossref_primary_10_1002_qsar_200320001 crossref_primary_10_3390_M693 crossref_primary_10_1002_cjoc_20020200711 crossref_primary_10_3390_M653 crossref_primary_10_1002_jhet_1585 crossref_primary_10_1081_SCC_120004068 crossref_primary_10_1016_S0040_4039_00_01645_2 crossref_primary_10_5012_bkcs_2013_34_6_1751 crossref_primary_10_1016_j_tetlet_2016_09_047 crossref_primary_10_3184_0308234041640799 crossref_primary_10_1039_c3ra23461d crossref_primary_10_1016_j_arabjc_2014_05_007 crossref_primary_10_1021_cc0601377 crossref_primary_10_1080_23312009_2015_1019809 crossref_primary_10_1080_00397911_2022_2117630 crossref_primary_10_1016_j_tet_2009_11_099 crossref_primary_10_1002_chin_199807174 crossref_primary_10_1080_10426500490474815 crossref_primary_10_1039_C6CY02038K crossref_primary_10_3987_COM_04_10312 crossref_primary_10_1134_S1070428017110100 crossref_primary_10_1016_j_ultsonch_2010_10_006 crossref_primary_10_1134_S1070363217020335 crossref_primary_10_1002_jhet_5570450633 crossref_primary_10_3390_30100001 crossref_primary_10_1007_s10562_004_3451_8 crossref_primary_10_1002_ardp_202000075 crossref_primary_10_1016_j_apcata_2016_06_015 crossref_primary_10_1021_jo000711f crossref_primary_10_1021_co4000503 crossref_primary_10_3184_030823405774909432 crossref_primary_10_1007_s13738_013_0395_1 crossref_primary_10_1016_j_tetlet_2008_09_045 crossref_primary_10_1007_s11243_005_5630_x crossref_primary_10_1039_b812901k crossref_primary_10_1021_jo040281j crossref_primary_10_1016_j_tet_2008_01_087 crossref_primary_10_1007_s00706_009_0156_0 crossref_primary_10_1002_jhet_2377 crossref_primary_10_1016_j_cclet_2012_10_015 crossref_primary_10_1021_jo102062u crossref_primary_10_3184_174751913X13573126386313 crossref_primary_10_1016_S0040_4039_03_00436_2 crossref_primary_10_1016_j_ultsonch_2008_02_014 crossref_primary_10_1016_j_tet_2006_11_010 crossref_primary_10_1021_jo0205199 crossref_primary_10_3184_030823402103170394 crossref_primary_10_4236_ijoc_2013_33A009 crossref_primary_10_1134_S107036321612015X crossref_primary_10_1016_j_ultsonch_2009_11_014 |
ContentType | Journal Article |
DBID | 1KM 1KN BLEPL DTL FCVLA |
DOI | 10.3987/com-97-7931 |
DatabaseName | Index Chemicus Current Chemical Reactions Web of Science Core Collection Science Citation Index Expanded Web of Science - Science Citation Index Expanded - 1997 |
DatabaseTitle | Web of Science |
DatabaseTitleList | Web of Science |
Database_xml | – sequence: 1 dbid: 1KN name: Current Chemical Reactions url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/woscc/search-with-editions?editions=WOS.CCR sourceTypes: Enrichment Source Index Database |
DeliveryMethod | no_fulltext_linktorsrc |
Discipline | Chemistry |
EndPage | 1978 |
ExternalDocumentID | A1997YF18000016 |
GroupedDBID | --K -~X 1B1 1KM 1KN 3L6 53G 5GY ABTAH AENEX AHWXS AI. ALMA_UNASSIGNED_HOLDINGS B.R BLEPL CS3 DTL DU5 EBS EJD F5P GROUPED_WOS_SCIENCE_CITATION_INDEX_EXPANDED IHE M41 P2P RIG RPZ SJN TN5 UPT VH1 XPP Y6R ZE2 ZY4 |
ID | FETCH-LOGICAL-c231t-81c29b948fcae5fae53e226ba790dc9f15edfdafe719ad3875da792680a170292 |
ISICitedReferencesCount | 81 |
ISICitedReferencesURI | https://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=CitingArticles&UT=A1997YF18000016 |
ISSN | 0385-5414 |
IngestDate | Thu Apr 20 20:11:32 EDT 2023 Fri Oct 18 19:55:22 EDT 2024 |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 10 |
Keywords | BLOCKERS OXIDATION ANTIHYPERTENSIVE AGENTS NITRATE HANTZSCH 1,4-DIHYDROPYRIDINES DIHYDROPYRIDINES TAUTOMERISM ACID-ESTERS PYRIDINIUM CHLOROCHROMATE POTENT MIMICS |
Language | English |
LinkModel | OpenURL |
LogoURL | https://exlibris-pub.s3.amazonaws.com/fromwos-v2.jpg |
MergedId | FETCHMERGED-LOGICAL-c231t-81c29b948fcae5fae53e226ba790dc9f15edfdafe719ad3875da792680a170292 |
ORCID | 0000-0003-2983-6007 |
PageCount | 12 |
ParticipantIDs | webofscience_primary_A1997YF18000016CitationCount webofscience_primary_A1997YF18000016 |
PublicationCentury | 1900 |
PublicationDate | 1997-00-00 |
PublicationDateYYYYMMDD | 1997-01-01 |
PublicationDate_xml | – year: 1997 text: 1997-00-00 |
PublicationDecade | 1990 |
PublicationPlace | OXFORD |
PublicationPlace_xml | – name: OXFORD |
PublicationTitle | Heterocycles |
PublicationTitleAbbrev | HETEROCYCLES |
PublicationYear | 1997 |
Publisher | Elsevier |
Publisher_xml | – name: Elsevier |
References | ROVNYAK, GC (WOS:A1995QB22700017) 1995; 38 ATWAL, KS (WOS:A1989CD77300020) 1989; 54 GROVER, GJ (WOS:A1995RL10900015) 1995; 26 Kappe, CO (WOS:A1997WZ55500021) 1997; 62 VANDENEYNDE, JJ (WOS:A1994NB47600025) 1994; 37 ATWAL, KS (WOS:A1991EX56300048) 1991; 34 CHO, H (WOS:A1988P227800054) 1988; 110 CHO, H (WOS:A1989AT15000029) 1989; 32 VANDENEYNDE, JJ (WOS:A1992HB15100007) 1992; 48 SAR, CP (WOS:A1994QL35700007) 1994; 131 ZIGEUNER, G (WOS:A19668515300013) 1966; 97 Prey, V (WOS:000201216800062) 1942; 75 FATIADI, AJ (WOS:A1976BF26500001) 1976 Kappe, CO (WOS:A1997WK21300010) 1997; 53 DOMMISSE, RA (WOS:A1977DU28100008) 1977; 86 ATWAL, KS (WOS:A1990DW33900044) 1990; 33 NEGWER M (WOS:A1997YF18000016.22) 1994 LIEPINSH, EE (WOS:A1981LM94700022) 1981 WEIS, AL (WOS:A1986C041500044) 1986; 24 FATIADI, AJ (WOS:A1976BJ76200001) 1976 VANDENEYNDE, JJ (WOS:A1995RA56800013) 1995; 51 MAQUESTIAU, A (WOS:A1991FX79700023) 1991; 32 Vanden Eynde, Jean-Jacques (BCI:BCI199497195568) 1994; 50 RADL S (WOS:A1997YF18000016.29) 1989; 7 KAMAL, A (WOS:A1964WN55200004) 1964; 37 HANKOVSZKY, OH (WOS:A1991EU00700026) 1991 WALKER, D (WOS:A19679088600002) 1967; 67 ATWAL, KS (WOS:A1990DA90600035) 1990; 33 KAPPE, CO (WOS:A1993LQ96200001) 1993; 49 PIANCATELLI, G (WOS:A1982NM88200001) 1982 FOLKERS K (WOS:A1997YF18000016.11) 1932; 54 (WOS:A1997YF18000016.1) 1978 ROVNYAK, GC (WOS:A1992JK32400023) 1992; 35 KHANINA EL (WOS:A1997YF18000016.18) 1982 Prey, V (WOS:000201216700050) 1941; 74 LOEV, B (WOS:A19656535400049) 1965; 30 PERRIN R (WOS:A1997YF18000016.24) 1993 OREILLY, BC (WOS:A1987G981500007) 1987; 26 PFISTER, JR (WOS:A1990DR68700017) 1990 VANDENEYNDE JJ (WOS:A1997YF18000016.33) 1995; 104 |
References_xml | – volume: 54 start-page: 3750 year: 1932 ident: WOS:A1997YF18000016.11 publication-title: J AM CHEM SOC contributor: fullname: FOLKERS K – volume: 37 start-page: 815 year: 1994 ident: WOS:A1994NB47600025 article-title: AN UNUSUAL AROMATIZATION OF HANTZSCH-TYPE 4-ANTIPYRYL-1,4-DIHYDROPYRIDINES publication-title: HETEROCYCLES contributor: fullname: VANDENEYNDE, JJ – start-page: 689 year: 1990 ident: WOS:A1990DR68700017 article-title: RAPID, HIGH-YIELD OXIDATION OF HANTZSCH-TYPE 1,4-DIHYDROPYRIDINES WITH CERIC AMMONIUM-NITRATE publication-title: SYNTHESIS-STUTTGART contributor: fullname: PFISTER, JR – volume: 26 start-page: 1185 year: 1987 ident: WOS:A1987G981500007 article-title: SYNTHESIS OF SUBSTITUTED 1,2,3,4-TETRAHYDRO-6-METHYL-2-OXO-5-PYRIMIDINECARBOXYLIC ACID-ESTERS - THE BIGINELLI CONDENSATION REVISITED publication-title: HETEROCYCLES contributor: fullname: OREILLY, BC – volume: 104 start-page: 387 year: 1995 ident: WOS:A1997YF18000016.33 publication-title: B SOC CHIM BELG contributor: fullname: VANDENEYNDE JJ – volume: 33 start-page: 1510 year: 1990 ident: WOS:A1990DA90600035 article-title: DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS - 2-HETEROSUBSTITUTED 4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: ATWAL, KS – volume: 48 start-page: 463 year: 1992 ident: WOS:A1992HB15100007 article-title: A NOVEL APPLICATION OF THE OXIDIZING PROPERTIES OF PYRIDINIUM CHLOROCHROMATE - AROMATIZATION OF HANTZSCH 1,4-DIHYDROPYRIDINES publication-title: TETRAHEDRON contributor: fullname: VANDENEYNDE, JJ – year: 1994 ident: WOS:A1997YF18000016.22 publication-title: ORGANIC CHEM DRUGS T contributor: fullname: NEGWER M – volume: 51 start-page: 6511 year: 1995 ident: WOS:A1995RA56800013 article-title: OLD REAGENTS, NEW RESULTS - AROMATIZATION OF HANTZSCH 1,4-DIHYDROPYRIDINES WITH MANGANESE-DIOXIDE AND 2,3-DICHLORO-5,6-DICYANO-1,4-BENZOQUINONE publication-title: TETRAHEDRON contributor: fullname: VANDENEYNDE, JJ – volume: 32 start-page: 2399 year: 1989 ident: WOS:A1989AT15000029 article-title: DIHYDROPYRIMIDINES - NOVEL CALCIUM-ANTAGONISTS WITH POTENT AND LONG-LASTING VASODILATIVE AND ANTIHYPERTENSIVE ACTIVITY publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: CHO, H – volume: 32 start-page: 3839 year: 1991 ident: WOS:A1991FX79700023 article-title: ULTRASOUND-PROMOTED AROMATIZATION OF HANTZSCH 1,4-DIHYDROPYRIDINES BY CLAY-SUPPORTED CUPRIC NITRATE publication-title: TETRAHEDRON LETTERS contributor: fullname: MAQUESTIAU, A – start-page: 65 year: 1976 ident: WOS:A1976BF26500001 article-title: ACTIVE MANGANESE-DIOXIDE OXIDATION IN ORGANIC-CHEMISTRY .1. publication-title: SYNTHESIS-STUTTGART contributor: fullname: FATIADI, AJ – year: 1978 ident: WOS:A1997YF18000016.1 – volume: 97 start-page: 1408 year: 1966 ident: WOS:A19668515300013 article-title: HETEROCYCLES .12. BROMINATION OF 2-OXO-6-METHYL-TETRAHYDROPYRIMIDINES publication-title: MONATSHEFTE FUR CHEMIE UND VERWANDTE TEILE ANDERER WISSENSCHAFTEN contributor: fullname: ZIGEUNER, G – volume: 67 start-page: 153 year: 1967 ident: WOS:A19679088600002 article-title: 2,3-DICHLORO-5,6-DICYANOBENZOQUINONE AND ITS REACTIONS publication-title: CHEMICAL REVIEWS contributor: fullname: WALKER, D – volume: 131 start-page: 363 year: 1994 ident: WOS:A1994QL35700007 article-title: SYNTHESIS, OXIDATION AND CLAISSEN REARRANGEMENT OF 4-(ALLYLOXY)PHENYL-1,4-DIHYDROPYRIDINES AND 4-(ALLYLOXY)PHENYL-1,4-DIHYDROPYRIMIDINES publication-title: ACH-MODELS IN CHEMISTRY contributor: fullname: SAR, CP – start-page: 91 year: 1991 ident: WOS:A1991EU00700026 article-title: SYNTHESIS OF SPIN-LABELED 1,4-DIHYDROPYRIDINES AND PYRIDINES publication-title: SYNTHESIS-STUTTGART contributor: fullname: HANKOVSZKY, OH – volume: 35 start-page: 3254 year: 1992 ident: WOS:A1992JK32400023 article-title: DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .4. BASIC 3-SUBSTITUTED-4-ARYL-1,4-DIHYDROPYRIMIDINE-5-CARBOXYLIC ACID-ESTERS - POTENT ANTIHYPERTENSIVE AGENTS publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: ROVNYAK, GC – start-page: 133 year: 1976 ident: WOS:A1976BJ76200001 article-title: ACTIVE MANGANESE-DIOXIDE OXIDATION IN ORGANIC-CHEMISTRY .2. publication-title: SYNTHESIS-STUTTGART contributor: fullname: FATIADI, AJ – volume: 110 start-page: 4832 year: 1988 ident: WOS:A1988P227800054 article-title: ON THE TAUTOMERISM OF DIHYDROPYRIMIDINES - THE INFLUENCE OF THE 2-SUBSTITUENT AND 5-SUBSTITUENT ON THE OBSERVATION OF TAUTOMERS publication-title: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY contributor: fullname: CHO, H – volume: 86 start-page: 633 year: 1977 ident: WOS:A1977DU28100008 article-title: KINETIC STUDY OF OXIDATION OF 1,4-DIHYDROPYRIDINES WITH CHLORANIL publication-title: BULLETIN DES SOCIETES CHIMIQUES BELGES contributor: fullname: DOMMISSE, RA – start-page: 535 year: 1982 ident: WOS:A1997YF18000016.18 publication-title: KHIM GETEROTSIKL+ contributor: fullname: KHANINA EL – volume: 33 start-page: 2629 year: 1990 ident: WOS:A1990DW33900044 article-title: DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .2. 3-SUBSTITUTED-4-ARYL-1,4-DIHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS POTENT MIMICS OF DIHYDROPYRIDINES publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: ATWAL, KS – start-page: 524 year: 1981 ident: WOS:A1981LM94700022 article-title: CONFORMATION OF 1,2,3,4-TETRAHYDROPYRIMIDINONES-2 publication-title: KHIMIYA GETEROTSIKLICHESKIKH SOEDINENII contributor: fullname: LIEPINSH, EE – volume: 24 start-page: 1433 year: 1986 ident: WOS:A1986C041500044 article-title: DIHYDROPYRIMIDINES - SYNTHESIS, STRUCTURE AND TAUTOMERISM publication-title: HETEROCYCLES contributor: fullname: WEIS, AL – volume: 26 start-page: 289 year: 1995 ident: WOS:A1995RL10900015 article-title: PHARMACOLOGICAL PROFILE OF THE DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS SQ-32,547 AND SQ-32,946 publication-title: JOURNAL OF CARDIOVASCULAR PHARMACOLOGY contributor: fullname: GROVER, GJ – volume: 7 start-page: 12 year: 1989 ident: WOS:A1997YF18000016.29 publication-title: JANSSEN CHIM ACTA contributor: fullname: RADL S – volume: 54 start-page: 5898 year: 1989 ident: WOS:A1989CD77300020 article-title: SUBSTITUTED 1,4-DIHYDROPYRIMIDINES .3. SYNTHESIS OF SELECTIVELY FUNCTIONALIZED 2-HETERO-1,4-DIHYDROPYRIMIDINES publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: ATWAL, KS – start-page: 245 year: 1982 ident: WOS:A1982NM88200001 article-title: PYRIDINIUM CHLOROCHROMATE - A VERSATILE OXIDANT IN ORGANIC-SYNTHESIS publication-title: SYNTHESIS-STUTTGART contributor: fullname: PIANCATELLI, G – volume: 74 start-page: 1219 year: 1941 ident: WOS:000201216700050 article-title: The splitting of phenolether with pyridin-hydrochloride. publication-title: BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT contributor: fullname: Prey, V – volume: 34 start-page: 806 year: 1991 ident: WOS:A1991EX56300048 article-title: DIHYDROPYRIMIDINE CALCIUM-CHANNEL BLOCKERS .3. 3-CARBAMOYL-4-ARYL-1,2,3,4-TETRAHYDRO-6-METHYL-5-PYRIMIDINECARBOXYLIC ACID-ESTERS AS ORALLY EFFECTIVE ANTIHYPERTENSIVE AGENTS publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: ATWAL, KS – volume: 49 start-page: 6937 year: 1993 ident: WOS:A1993LQ96200001 article-title: 100 YEARS OF THE BIGINELLI DIHYDROPYRIMIDINE SYNTHESIS publication-title: TETRAHEDRON contributor: fullname: KAPPE, CO – volume: 75 start-page: 445 year: 1942 ident: WOS:000201216800062 article-title: The rays of phenolathern with pyridine-hydrochloride, III. Announcement: Tests on the quantitive classification of the methoxylgroup in phenolathern with pyridine hydrochloride. publication-title: BERICHTE DER DEUTSCHEN CHEMISCHEN GESELLSCHAFT contributor: fullname: Prey, V – year: 1993 ident: WOS:A1997YF18000016.24 publication-title: CHIMIE IND contributor: fullname: PERRIN R – volume: 38 start-page: 119 year: 1995 ident: WOS:A1995QB22700017 article-title: CALCIUM-ENTRY BLOCKERS AND ACTIVATORS - CONFORMATIONAL AND STRUCTURAL DETERMINANTS OF DIHYDROPYRIMIDINE CALCIUM-CHANNEL MODULATORS publication-title: JOURNAL OF MEDICINAL CHEMISTRY contributor: fullname: ROVNYAK, GC – volume: 50 start-page: 2479 year: 1994 ident: BCI:BCI199497195568 article-title: Potassium permanganate, a versatile reagent for the aromatization of Hantzsch 1,4-dihydropyridines publication-title: Tetrahedron contributor: fullname: Vanden Eynde, Jean-Jacques – volume: 62 start-page: 3109 year: 1997 ident: WOS:A1997WZ55500021 article-title: Dipolar cycloaddition reactions of dihydropyrimidine-fused mesomeric betaines. An approach toward conformationally restricted dihydropyrimidine derivatives publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: Kappe, CO – volume: 53 start-page: 2803 year: 1997 ident: WOS:A1997WK21300010 article-title: Synthesis and reactions of biginelli compounds .6. Conformational analysis of 4-aryl-dihydropyrimidine calcium channel modulators. A comparison of ab initio, semiempirical and X-ray crystallographic studies. publication-title: TETRAHEDRON contributor: fullname: Kappe, CO – volume: 30 start-page: 1914 year: 1965 ident: WOS:A19656535400049 article-title: HANTZSCH REACTION .I. OXIDATIVE DEALKYLATION OF CERTAIN DIHYDROPYRIDINES publication-title: JOURNAL OF ORGANIC CHEMISTRY contributor: fullname: LOEV, B – volume: 37 start-page: 610 year: 1964 ident: WOS:A1964WN55200004 article-title: AROMATIZATION OF SOME 4-SUBSTITUTED 2,6-DIMETHYL-3,5-DIETHOXYCARBONYL-1,4-DIHYDROPYRIDINES TO PYRIDINES publication-title: BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN contributor: fullname: KAMAL, A |
SSID | ssj0008088 |
Score | 1.81613 |
Snippet | A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the... |
Source | Web of Science |
SourceID | webofscience |
SourceType | Enrichment Source Index Database |
StartPage | 1967 |
SubjectTerms | Chemistry Chemistry, Organic Physical Sciences Science & Technology |
Title | Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type |
URI | http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestApp=WOS&DestLinkType=FullRecord&UT=A1997YF18000016 |
Volume | 45 |
WOS | A1997YF18000016 |
WOSCitedRecordID | wosA1997YF18000016 |
hasFullText | |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEBab9tBeSp80faFDbsWt5ZfkY1iyLCntpQmkpyDrQQOpHYITcHLKP--MZGtVN4dtD2sW72IZfx8zn0fzIGTPcGO4TXViMQ5WcG0TWXGZVKUpVKVTmymXbfGtWh8XhyflyWJxF1eX9M0ndXNvXcn_oArnAFeskv0HZMNF4QR8B3zhCAjDcSuMvw8t6DdsKeJarl52KD9vggjUZz8HfdldDDi6S2N--0ffLhZbbZwPvo4FBCfIT0BKnV39cnXArTnHATk41wsn8YxJBJgDo3HQtUkwbBuL2jWm1HRqwAS7CcBrDE63B0Pr2_oehnD0_hUw0tcJhV2gpWwx3yaA79JTN3FZPVbp8VlQYqqWiYxZLsoER47Hltc3kpwYlkZ2FOwCj3wyq_2cn7m9z13EZIXuBO4BTA3buLVpK3_m7UIOIvb75T9WTLgNjmqH7HCBJpJ9-RpcuUjd4NJw877AE1f9HK15r2Zx-uToKXkyvljQfc-SZ2Rh2ufk0XKa5_eC3Aa2UMCG_sEW2ln6N1tozBY6soX2HR3ZQke20A1b8EKwCJ2x5SU5Xh0cLdfJOHojUSD4-0QwldVNXQirpCktfHIDQr2RvE61qi0rjbZaWsNZLXUOL70afsoqkUrG06zOXpEHwBzzmlCuZZ6DOwalKYuG1SJrQPU3mqlSMMvZLtmLn97phe-ycjrDZ5ewbf62HDvbY0eH_s12l35LHm84_I48tGAezHvQmn3zwfHhN2T5iZY |
link.rule.ids | 786 |
linkProvider | Clarivate |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Synthesis+and+aromatization+of+dihydropyrimidines+structurally+related+to+calcium+channel+modulators+of+the+nifedipine-type&rft.jtitle=Heterocycles&rft.au=vandenEynde%2C+JJ&rft.au=Audiart%2C+N&rft.au=Canonne&rft.au=Michel%2C+S&rft.date=1997-01-01&rft.pub=Elsevier&rft.issn=0385-5414&rft.volume=45&rft.issue=10&rft.spage=1967&rft.epage=1978&rft_id=info:doi/10.3987%2Fcom-97-7931&rft.externalDBID=n%2Fa&rft.externalDocID=A1997YF18000016 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0385-5414&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0385-5414&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0385-5414&client=summon |