Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type

A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which...

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Published inHeterocycles Vol. 45; no. 10; pp. 1967 - 1978
Main Authors vandenEynde, JJ, Audiart, N, Canonne, Michel, S, VanHaverbeke, Y, Kappe, CO
Format Journal Article
LanguageEnglish
Published OXFORD Elsevier 1997
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
BLOCKERS
OXIDATION
ANTIHYPERTENSIVE AGENTS
NITRATE
HANTZSCH 1,4-DIHYDROPYRIDINES
DIHYDROPYRIDINES
TAUTOMERISM
ACID-ESTERS
PYRIDINIUM CHLOROCHROMATE
POTENT MIMICS
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Abstract A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.
AbstractList A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain.
Author vandenEynde, JJ
VanHaverbeke, Y
Audiart, N
Michel, S
Kappe, CO
Canonne
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Issue 10
Keywords BLOCKERS
OXIDATION
ANTIHYPERTENSIVE AGENTS
NITRATE
HANTZSCH 1,4-DIHYDROPYRIDINES
DIHYDROPYRIDINES
TAUTOMERISM
ACID-ESTERS
PYRIDINIUM CHLOROCHROMATE
POTENT MIMICS
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SSID ssj0008088
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Snippet A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the...
Source Web of Science
SourceID webofscience
SourceType Enrichment Source
Index Database
StartPage 1967
SubjectTerms Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
Title Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type
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