Synthesis and aromatization of dihydropyrimidines structurally related to calcium channel modulators of the nifedipine-type
A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which...
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Published in | Heterocycles Vol. 45; no. 10; pp. 1967 - 1978 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
OXFORD
Elsevier
1997
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Subjects | |
Online Access | Get more information |
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Summary: | A series of 4-substituted ethyl 2-methoxy-6-methyl-1,4-dihydropyrimidine-5-carboxylates has been synthesized and was successfully aromatized to the corresponding pyrimidines with various oxidizing reagents. O-Demethylation of such pyrimidines provides a simple route to pyrimidinone derivatives which are otherwise difficult to obtain. |
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ISSN: | 0385-5414 |
DOI: | 10.3987/com-97-7931 |