The three YTHDF paralogs and VIRMA are strong cross-histotype tumor driver candidates among m6A core genes

• Published in: NAR cancer Vol. 6; no. 4; p. zcae040
• Main Authors: Destefanis, Eliana, Sighel, Denise, Dalfovo, Davide, Gilmozzi, Riccardo, Broso, Francesca, Cappannini, Andrea, Bujnicki, Janusz M, Romanel, Alessandro, Dassi, Erik, Quattrone, Alessandro
• Format: Journal Article
• Language: English
• Published: Oxford University Press 01.12.2024

N6-Methyladenosine (m6A) is the most abundant internal modification in mRNAs. Despite accumulating evidence for the profound impact of m6A on cancer biology, there are conflicting reports that alterations in genes encoding the m6A machinery proteins can either promote or suppress cancer, even in the...