The effect of vasopressin on the expression of genes of key enzymes of the interstitial hyaluronan turnover and concentration ability in WAG rat kidneys
In mammals arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via the increase of the osmotic permeability of the epithelium of the collecting duct. The AVP-induced intracellular events include, as a core step, the trafficking of the vesicles...
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Published in | Russian journal of genetics. Applied research Vol. 7; no. 3; pp. 249 - 257 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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01.05.2017
Springer Nature B.V |
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Abstract | In mammals arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via the increase of the osmotic permeability of the epithelium of the collecting duct. The AVP-induced intracellular events include, as a core step, the trafficking of the vesicles containing the water channels, aquaporin-2, to the apical plasma membrane of the collecting duct’s principal cells. The interstitium of the renal inner medulla contains abundant linear negatively charged glycosaminoglycan, hyaluronan (HA), which affects the water flow between structures of the concentrating mechanism, depending on its polymeric state. Using real-time RT-PCR, we tested the assumption that the renal hyaluronan may be involved in the long-term vasopressin effect on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 (
Has2
), hyaluronidase-1, and hyaluronidase-2 (
Hyal1
and
Hyal2
) in the kidneys of Wistar Albino Glaxo (WAG) was studied. The
Has2
mRNA content was the highest in the papilla of the kidneys of the hydrated rats. The V
2
receptor-selective vasopressin analog dDAVP (100 μg/kg of body weight, twice a day intraperitoneally for 2 days) induced a considerable decrease in the
Has2
mRNA content in the papilla with less pronounced changes in the cortex. In contrast to
Has2
, the dDAVP treatment caused a significant increase in the
Hyal1
and
Hyal2
mRNA content in the renal papilla. There was a good fit between the
Hyal1
and
Hyal2
transcriptional levels and changes in hyaluronidase activity in the renal tissue. It was suggested that vasopressin is able to inhibit the synthesis of hyaluronan and concomitantly promotes its degradation in the renal papilla interstitium, thereby facilitating water flow between the elements of the renal countercurrent system. The implications for this effect are discussed in the context of the data in the literature. |
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AbstractList | In mammals arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via the increase of the osmotic permeability of the epithelium of the collecting duct. The AVP-induced intracellular events include, as a core step, the trafficking of the vesicles containing the water channels, aquaporin-2, to the apical plasma membrane of the collecting duct’s principal cells. The interstitium of the renal inner medulla contains abundant linear negatively charged glycosaminoglycan, hyaluronan (HA), which affects the water flow between structures of the concentrating mechanism, depending on its polymeric state. Using real-time RT-PCR, we tested the assumption that the renal hyaluronan may be involved in the long-term vasopressin effect on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 (Has2), hyaluronidase-1, and hyaluronidase-2 (Hyal1 and Hyal2) in the kidneys of Wistar Albino Glaxo (WAG) was studied. The Has2 mRNA content was the highest in the papilla of the kidneys of the hydrated rats. The V2 receptor-selective vasopressin analog dDAVP (100 μg/kg of body weight, twice a day intraperitoneally for 2 days) induced a considerable decrease in the Has2 mRNA content in the papilla with less pronounced changes in the cortex. In contrast to Has2, the dDAVP treatment caused a significant increase in the Hyal1 and Hyal2 mRNA content in the renal papilla. There was a good fit between the Hyal1 and Hyal2 transcriptional levels and changes in hyaluronidase activity in the renal tissue. It was suggested that vasopressin is able to inhibit the synthesis of hyaluronan and concomitantly promotes its degradation in the renal papilla interstitium, thereby facilitating water flow between the elements of the renal countercurrent system. The implications for this effect are discussed in the context of the data in the literature. In mammals arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via the increase of the osmotic permeability of the epithelium of the collecting duct. The AVP-induced intracellular events include, as a core step, the trafficking of the vesicles containing the water channels, aquaporin-2, to the apical plasma membrane of the collecting duct’s principal cells. The interstitium of the renal inner medulla contains abundant linear negatively charged glycosaminoglycan, hyaluronan (HA), which affects the water flow between structures of the concentrating mechanism, depending on its polymeric state. Using real-time RT-PCR, we tested the assumption that the renal hyaluronan may be involved in the long-term vasopressin effect on water reabsorption. The expression of the genes encoding hyaluronan synthase-2 ( Has2 ), hyaluronidase-1, and hyaluronidase-2 ( Hyal1 and Hyal2 ) in the kidneys of Wistar Albino Glaxo (WAG) was studied. The Has2 mRNA content was the highest in the papilla of the kidneys of the hydrated rats. The V 2 receptor-selective vasopressin analog dDAVP (100 μg/kg of body weight, twice a day intraperitoneally for 2 days) induced a considerable decrease in the Has2 mRNA content in the papilla with less pronounced changes in the cortex. In contrast to Has2 , the dDAVP treatment caused a significant increase in the Hyal1 and Hyal2 mRNA content in the renal papilla. There was a good fit between the Hyal1 and Hyal2 transcriptional levels and changes in hyaluronidase activity in the renal tissue. It was suggested that vasopressin is able to inhibit the synthesis of hyaluronan and concomitantly promotes its degradation in the renal papilla interstitium, thereby facilitating water flow between the elements of the renal countercurrent system. The implications for this effect are discussed in the context of the data in the literature. |
Author | Baturina, G. S. Katkova, L. E. Ivanova, L. N. Babina, A. V. |
Author_xml | – sequence: 1 givenname: L. N. surname: Ivanova fullname: Ivanova, L. N. organization: Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk State University – sequence: 2 givenname: A. V. surname: Babina fullname: Babina, A. V. email: alvit@bionet.nsc.ru organization: Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk State University – sequence: 3 givenname: G. S. surname: Baturina fullname: Baturina, G. S. organization: Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences – sequence: 4 givenname: L. E. surname: Katkova fullname: Katkova, L. E. organization: Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences |
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Cites_doi | 10.1007/s004240100575 10.1111/j.1749-6632.1982.tb37462.x 10.1074/jbc.273.4.1923 10.1074/jbc.271.17.9875 10.1016/S0945-053X(01)00172-X 10.1002/prot.20592 10.1152/ajpregu.00332.2011 10.1016/j.ab.2003.08.005 10.1152/ajprenal.00067.2002 10.1016/j.cbpa.2007.08.027 10.1016/j.matbio.2005.11.005 10.1016/S0014-4835(63)80002-0 10.1016/j.matbio.2009.07.002 10.1038/1821218a0 10.1111/j.1768-322X.1997.tb01021.x 10.1152/physrev.00024.2001 10.1038/ki.1987.35 10.1159/000228082 10.1152/physiolgenomics.00201.2007 10.1073/pnas.0910646107 10.1152/ajprenal.00054.2002 10.1111/j.1523-1755.2000.00378.x 10.1111/j.1748-1716.2007.01795.x 10.1007/s10540-005-2577-2 10.1042/bj3480029 10.1093/glycob/cwg112 10.1074/jbc.M608358200 10.1042/BC20040120 10.1042/bj0960449 10.1016/S0955-0674(00)00135-6 10.1113/jphysiol.1952.sp004728 10.1007/BF00785968 10.1152/physrev.1978.58.1.255 |
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Keywords | water reabsorption kidney hyaluronidase-1 2 hyaluronansynthase-2 hyaluronan vasopressin gene expression |
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Snippet | In mammals arginine-vasopressin (AVP) is a major hormone involved in the regulation of renal water reabsorption, acting via the increase of the osmotic... |
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SubjectTerms | Aquaporins Arginine Argipressin Biomedical and Life Sciences Biomedicine Body weight Collecting duct Enzymes Epithelium Human Genetics Hyaluronan synthase Hyaluronic acid Kidneys Permeability Polymerase chain reaction Reabsorption Rodents Sodium Transcription Vasopressin Water flow |
Title | The effect of vasopressin on the expression of genes of key enzymes of the interstitial hyaluronan turnover and concentration ability in WAG rat kidneys |
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