Transgenerational genomic instability in the first generation offspring of mice exposed to low-intensity red and near-infrared irradiation in vivo

• Published in: Biophysics (Oxford) Vol. 62; no. 5; pp. 836 - 841
• Main Authors: Zaichkina, S. I., Dyukina, A. R., Rozanova, O. M., Romanchenko, S. P., Simonova, N. B., Sorokina, S. S., Yusupov, V. I., Bagratashvili, V. N.
• Format: Journal Article
• Language: English
• Published: Moscow Pleiades Publishing 01.09.2017; Springer Nature B.V
• Subjects: Adaptive radiation; Biological and Medical Physics; Biophysics; Biophysics of Complex Systems; Bone marrow; Exposure; Genomic instability; Growth rate; I.R. radiation; Infrared lasers; Infrared radiation; Irradiation; Mice; Offspring; Organs; Physics; Physics and Astronomy; Radiation; Radiosensitivity; Reactive oxygen species; infrared light; red light; transgenerational genomic instability; mice; X-rays
• ISSN: 0006-3509; 1555-6654
• DOI: 10.1134/S0006350917050244

Transgenerational genomic instability in the first generation offspring of mice exposed to lowintensity infrared laser (632.8 nm) and light-emitting-diode infrared irradiation (850 nm) was investigated in vivo. It was found that the level of spontaneous damage in bone marrow according to the micronucleus test, the level of reactive oxygen species in whole blood, and the mass index of lymphoid organs in all of the descendants of irradiated mice did not increase. After additional X-ray exposure of the progeny at a dose rate of 1.5 Gy, a decrease in the level of damage and the absence of an adaptive response were revealed upon testing according to “radiosensitivity” and the radiation-induced adaptive-response scheme (0.1 + 1.5 Gy), respectively, compared to the descendants of nonirradiated mice. The rate of tumor growth in the offspring of irradiated mice did not differ from that in the descendants of nonirradiated mice, although inhibition of the tumor growth rate was observed in their irradiated parents. The survival rate after irradiation at a dose rate of 6.5 Gy did not differ from both the parents and the control.