Does stereotactic eligibility for the treatment of glioblastoma cause selection bias in randomized studies?

• Published in: American journal of clinical oncology Vol. 27; no. 5; p. 516
• Main Authors: Lustig, Robert A, Scott, Charles B, Curran, Walter J
• Format: Journal Article
• Language: English
• Published: United States 01.10.2004
• Subjects: Adult; Aged; Antineoplastic Agents, Alkylating - therapeutic use; Carmustine - therapeutic use; Central Nervous System Neoplasms - classification; Central Nervous System Neoplasms - drug therapy; Central Nervous System Neoplasms - radiotherapy; Central Nervous System Neoplasms - surgery; Combined Modality Therapy; Female; Glioblastoma - classification; Glioblastoma - drug therapy; Glioblastoma - radiotherapy; Glioblastoma - surgery; Humans; Male; Middle Aged; Patient Selection; Prognosis; Radiosurgery; Randomized Controlled Trials as Topic; Selection Bias; Survival Analysis

The purpose of this study was to evaluate the potential selection bias using stereotactic eligibility as a criteria for participation in studies of glioblastoma multiforme. Radiation Therapy Oncology Group (RTOG) 90-06 comparing 60 Gy in 30 fractions with BCNU and 72 Gy in 60 fractions with BCNU was...