How to identify and characterize novel transaminases? Two novel transaminases with opposite enantioselectivity for the synthesis of optically active amines

• Published in: Molecular catalysis Vol. 531; p. 112660
• Main Authors: Gal, Cristian Andrei, Barabás, Laura-Edit, Varga, Andrea, Csuka, Pál, Bencze, László Csaba, Toșa, Monica Ioana, Poppe, László, Paizs, Csaba
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.10.2022
• Subjects: Enzyme kinetics; Enzyme stability; Kinetic resolution; Synthesis of enantiopure (R)- and (S)-amines; Transaminases; Enzyme kinetics; Kinetic resolution; Enzyme stability; Transaminases; Synthesis of enantiopure (R)- and (S)-amines

•Discovery of two novel amine transaminases with opposite stereopreference.•Operational activity/stability assessment of the new amine transaminases.•Biocatalytic synthesis of enantiopure (R)- and (S)-1-arylethane-1-amines. Amine transaminases (TAs) are attractive biocatalysts for the synthesis of c...