Cytotoxic effects of indium(III) complexes with 2-acetylpyridine-N(4)-ortho-fluorophenylthiosemicarbazone and their radioactive 114mIn analogues against human glioma cells

• Published in: Polyhedron Vol. 164; pp. 219 - 227
• Main Authors: Aguirre, Andrea R., Parrilha, Gabrieli L., Diniz, Renata, Ribeiro, Beatriz Cancelier, Santos, Raquel G. Dos, Beraldo, Heloisa
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 15.05.2019; Elsevier
• Subjects: Chemistry; Chemistry, Inorganic & Nuclear; Crystallography; Cytotoxicity; Glioblastoma Cells; Indium; Physical Sciences; Radiopharmaceuticals; Science & Technology; Thiosemicarbazones; Cytotoxicity; Indium; Radiopharmaceuticals; Glioblastoma Cells; Thiosemicarbazones; IN(III) COMPLEXES; LIGANDS; MOLECULAR-STRUCTURE; GALLIUM(III); 2-ACETYLPYRIDINE THIOSEMICARBAZONES; CRYSTAL; BINDING

Complexes [In(2Ac4oFPh)Cl2(MeOH)] (1) and [In(2Ac4oFPh)Cl2] (2) were obtained with 2-acetylpyridine-N(4)-ortho-fluorophenyl thiosemicarbazone. Neutron activation of (1) and (2) resulted in the formation of the 114mIn/115mIn analogues (*1) and (*2). The non-radioactive and radioactive complexes showe...