Tissue factor and human apolipoprotein H genetic variants and pro-inflammatory cytokines in systemic lupus erythematosus patients

• Published in: Clinical and experimental rheumatology Vol. 39; no. 3; p. 587
• Main Authors: Wajda, Anna, Sowińska, Anna, Haładyj, Ewa, Stypińska, Barbara, Nałęcz-Janik, Jolanta, Jagodziński, Pawel Piotr, Majewski, Dominik, Olesińska, Marzena, Paradowska-Gorycka, Agnieszka
• Format: Journal Article
• Language: English
• Published: Italy 01.05.2021
• Subjects: beta 2-Glycoprotein I - genetics; Case-Control Studies; Cytokines - genetics; Humans; Lupus Erythematosus, Systemic - genetics; Polymorphism, Single Nucleotide; Thromboplastin - genetics
• DOI: 10.55563/clinexprheumatol/5lkj3f
• ISSN: 0392-856X

Tissue factor (TF) and Human apolipoprotein H (APOH) seem to be significantly associated with a clinical manifestation in systemic lupus erythematosus (SLE) patients with or without APS, mostly because of thrombotic events and coagulation processes. Additionally, according to recent studies, these two factors appear to be an important part of immune response and inflammation. The objective of this study was to investigate three SNPs of APOH (rs4581, rs8178835 and rs818819) and three of TF (rs958587, rs3917615, rs1361600) in SLE patients and healthy subjects using TaqMan genotyping assay and their association with inflammatory cytokines level in serum and selected clinical parameters. Present study revealed that TF rs3917615 and rs958587 and APOH rs4581 possibly predispose to joint involvement in SLE. Analysed genetic variants of TF and APOH may have an impact on inflammatory processes and clinical relevance in SLE patients in the Caucasian population.