An engineered decoy receptor for SARS-CoV-2 broadly binds protein S sequence variants

• Published in: bioRxiv
• Main Authors: Chan, Kui K, Tan, Timothy J C, Narayanan, Krishna K, Procko, Erik
• Format: Journal Article Paper
• Language: English
• Published: United States Cold Spring Harbor Laboratory Press 21.12.2020
• Subjects: ACE2; Affinity; Amino acid sequence; Angiotensin-converting enzyme 2; Binding sites; Cell membranes; Mutants; Protein S; Saturation mutagenesis; Severe acute respiratory syndrome coronavirus 2

The spike S of SARS-CoV-2 recognizes ACE2 on the host cell membrane to initiate entry. Soluble decoy receptors, in which the ACE2 ectodomain is engineered to block S with high affinity, potently neutralize infection and, due to close similarity with the natural receptor, hold out the promise of bein...