Evolution of the primary and secondary structures of the E1a mRNAs of the adenovirus

• Published in: Molecular biology and evolution Vol. 4; no. 3; p. 300
• Main Authors: Konings, D A, Hogeweg, P, Hesper, B
• Format: Journal Article
• Language: English
• Published: United States 01.05.1987
• Subjects: Adenoviridae - genetics; Adenovirus Early Proteins; Adenoviruses, Human - genetics; Adenoviruses, Human - immunology; Adenoviruses, Simian - genetics; Adenoviruses, Simian - immunology; Antigens, Viral, Tumor - genetics; Base Sequence; Biological Evolution; Molecular Sequence Data; Nucleic Acid Conformation; Oncogene Proteins, Viral - genetics; RNA, Messenger - genetics; Sequence Homology, Nucleic Acid

In this paper we investigate and compare (evolutionary) patterns in the primary and secondary structure of four homologous E1a mRNAs of the adenovirus. Our main results are as follows: (1) The similarity of the coding regions of the mRNA sequences reflects both similarity in function (i.e., oncogeni...