Self-Protection against the Sphingolipid Biosynthesis Inhibitor Fumonisin B 1 Is Conferred by a FUM Cluster-Encoded Ceramide Synthase

• Published in: mBio Vol. 11; no. 3
• Main Authors: Janevska, Slavica, Ferling, Iuliia, Jojić, Katarina, Rautschek, Julia, Hoefgen, Sandra, Proctor, Robert H, Hillmann, Falk, Valiante, Vito
• Format: Journal Article
• Language: English
• Published: United States 30.06.2020
• Subjects: Biosynthetic Pathways - genetics; Cell Compartmentation; Ceramides - biosynthesis; Endoplasmic Reticulum - metabolism; Fumonisins - metabolism; Fusarium - enzymology; Fusarium - genetics; Gene Expression Regulation, Fungal; Genes, Fungal; Multigene Family; Oxidoreductases - genetics; Oxidoreductases - metabolism; Phylogeny; Sphingolipids - antagonists & inhibitors; Sphingolipids - biosynthesis; Fusarium; ceramide synthase; ABC transporter; fumonisin B1; metabolite compartmentalization

Fumonisin (FB) mycotoxins produced by species of the genus detrimentally affect human and animal health upon consumption, due to the inhibition of ceramide synthase. In the present work, we set out to identify mechanisms of self-protection employed by the FB producer FB biosynthesis was shown to be...