Hepatitis B virus core protein interacts with the C-terminal region of actin-binding protein

• Published in: Journal of biomedical science Vol. 7; no. 2; pp. 160 - 168
• Main Authors: Huang, Chiu-Jung, Chen, Yuan-Han, Ting, Ling-Pai
• Format: Journal Article
• Language: English
• Published: England 01.03.2000
• Subjects: ABP-276/278 protein; ACP protein; Amino Acid Sequence; Contractile Proteins - chemistry; Contractile Proteins - metabolism; DNA, Complementary - genetics; Filamins; Gene Library; Hepatitis B Core Antigens - chemistry; Hepatitis B Core Antigens - metabolism; Hepatitis B virus; Hepatitis B virus - physiology; Humans; Microfilament Proteins - chemistry; Microfilament Proteins - metabolism; Molecular Sequence Data; Protein Binding; Protein Precursors - chemistry; Protein Precursors - metabolism; Protein Structure, Tertiary; Recombinant Fusion Proteins - metabolism; Two-Hybrid System Techniques; Virus Replication

Hepatitis B viral core protein is present in the nucleus and cytoplasm of infected hepatocytes. There is a strong correlation between the intrahepatic distribution of core protein and the viral replication state and disease activity in patients with chronic hepatitis. To understand the role of core...