GABAA receptor- and GABA transporter polymorphisms and risk for essential tremor

• Published in: European journal of neurology Vol. 18; no. 8; pp. 1098 - 1100
• Main Authors: Thier, S., Kuhlenbäumer, G., Lorenz, D., Nothnagel, M., Nebel, A., Christensen, K., Schreiber, S., Deuschl, G., Klebe, S.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011
• Subjects: Animal models; association study; essential tremor; GABA transporters; GABA(A) receptors; gamma -Aminobutyric acid; gamma -Aminobutyric acid A receptors; gamma -Aminobutyric acid transporter; Gene polymorphism; Single-nucleotide polymorphism; tremor

Background:  Clinical features and animal models of essential tremor (ET) suggest gamma‐aminobutyric acid A receptor (GABAAR) subunits and GABA transporters as putative candidate genes. Methods:  A total of 503 ET cases and 818 controls were investigated for an association between polymorphisms in 1...