IRF1 transcriptionally activates ALOX15B to enhance ferroptosis sensitivity in triple-negative breast cancer

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 10; p. 130846
• Main Authors: Peng, Wei, Xie, Yi, Duan, Bofeng, Qian, Fuyong, Fan, Zhifeng, Zheng, Wei
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025
• Subjects: 15-lipoxygenase; Arachidonate 12-Lipoxygenase - genetics; Arachidonate 12-Lipoxygenase - metabolism; Arachidonate 15-Lipoxygenase - genetics; Arachidonate 15-Lipoxygenase - metabolism; Breast cancer; Cell Line, Tumor; Female; Ferroptosis; Ferroptosis - genetics; Gene Expression Regulation, Neoplastic; Humans; Interferon regulatory factor; Interferon Regulatory Factor-1 - genetics; Interferon Regulatory Factor-1 - metabolism; Reactive Oxygen Species - metabolism; Transcriptional Activation; Triple Negative Breast Neoplasms - genetics; Triple Negative Breast Neoplasms - metabolism; Triple Negative Breast Neoplasms - pathology; Ferroptosis; Breast cancer; 15-lipoxygenase; Interferon regulatory factor

This study focused on the transcriptional activation of arachidonate 15-lipoxygenase type B (ALOX15B) by interferon regulatory factor 1 (IRF1) to promote ferroptosis in triple-negative breast cancer (TNBC) cells. In this study, TNBC and adjacent non-cancerous tissues were collected to detect ALOX15B...