Lineage contribution of the mesendoderm progenitors in the gastrulating mouse embryo

• Published in: Developmental cell Vol. 60; no. 14; pp. 1991 - 2006.e9
• Main Authors: Masamsetti, V. Pragathi, Salehin, Nazmus, Kim, Hani Jieun, Santucci, Nicole, Weatherstone, Megan, McMahon, Riley, Marshall, Lee L., Knowles, Hilary, Sun, Jane, Studdert, Josh B., Aryamanesh, Nader, Wang, Ran, Jing, Naihe, Yang, Pengyi, Osteil, Pierre, Tam, Patrick P.L.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 21.07.2025
• Subjects: Animals; Cell Differentiation; Cell Lineage; Embryo, Mammalian - cytology; Embryo, Mammalian - metabolism; endoderm; Endoderm - cytology; Endoderm - metabolism; endoderm differentiation; gastrulation; Gastrulation - physiology; Gene Expression Regulation, Developmental; Germ Layers - cytology; Germ Layers - metabolism; Homeodomain Proteins - genetics; Homeodomain Proteins - metabolism; lineage differentiation; mesendoderm; Mesoderm - cytology; Mesoderm - metabolism; Mice; micropattern; mouse embryos; mouse epiblast stem cells; single cell RNA sequencing analyis; Stem Cells - cytology; Stem Cells - metabolism; mesendoderm; micropattern; lineage differentiation; mouse epiblast stem cells; single cell RNA sequencing analyis; endoderm; mouse embryos; endoderm differentiation; gastrulation

A population of putative mesendoderm progenitors that can contribute cellular descendants to both mesoderm and endoderm lineages is identified in the gastrulating mouse embryo. These progenitor cells are localized to the posterior epiblast, primitive streak, and nascent mesoderm of mid-streak- (E7.0...