MiR-2779-x, a key microRNA that is related to the tumorigenicity of the MDCK cell line

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 10; p. 130843
• Main Authors: Yang, Di, Huang, Lingwei, Shi, Jiachen, Liu, Zhenbin, Wang, Jiamin, Ma, Zhongren, Abudureyimu, Ayimuguli, Qiao, Zilin, Chen, Jianguo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025
• Subjects: Animals; Carcinogenesis - genetics; Caspase 9 - genetics; Cell Movement - genetics; Cell Proliferation; Class Ia Phosphatidylinositol 3-Kinase - genetics; Dogs; Fluorescent Antibody Technique; Madin Darby Canine Kidney Cells - pathology; MDCK cell line; Mice; Mice, Nude; MicroRNAs - genetics; MicroRNAs - metabolism; miR-2779-x; Real-Time Polymerase Chain Reaction; Tumorigenicity; Vaccine Development; Vaccine safety; Vaccine safety; Tumorigenicity; miR-2779-x; MDCK cell line
• ISSN: 0304-4165; 1872-8006; 1872-8006
• DOI: 10.1016/j.bbagen.2025.130843

The tumorigenicity of MDCK cell line is a major concern with respect to its safety for vaccine production, the effect of miRNAs on the tumorigenicity of MDCK cells is poorly understood. In this study, we performed miRNA-Seq on two MDCK cell lines with tumorigenic potential and their derived monoclon...