Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction

• Published in: Chinese journal of natural medicines Vol. 22; no. 5; pp. 402 - 415
• Main Authors: XIU, Ye, WANG, Sihao, ZHANG, Ping, LI, Chengwei, WU, Zhixin, WEN, Jincai, XU, Yingjie, LV, Guiji, ZHAO, Xiaomei, DONG, Xu, CHEN, Yichong, LI, Junjie, WANG, Yan, ZOU, Liang, XIAO, Xiaohe, BAI, Zhaofang
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.05.2024
• Subjects: Animals; cGAS-STING pathway; Glucosides - pharmacology; Humans; Inflammation; Interferon Regulatory Factor-3 - metabolism; LPS/D-GalN; Macrophages - drug effects; Macrophages - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Nucleotidyltransferases - genetics; Nucleotidyltransferases - metabolism; Paeonia - chemistry; Signal Transduction - drug effects; STING inhibitor; THP-1 Cells; Total glucosides of gaeony; LPS/D-GalN; Inflammation; STING inhibitor; Total glucosides of gaeony; cGAS-STING pathway

In the realm of autoimmune and inflammatory diseases, the cyclic GMP-AMP synthase (cGAS) stimulator of interferon genes (STING) signaling pathway has been thoroughly investigated and established. Despite this, the clinical approval of drugs targeting the cGAS-STING pathway has been limited. The Tota...