Total glucosides of paeony alleviates cGAS-STING-mediated diseases by blocking the STING-IRF3 interaction - XIU, Ye; WANG, Sihao; ZHANG, Ping; LI, Chengwei; WU, Zhixin; WEN, Jincai; XU, Yingjie; LV, Guiji; ZHAO, Xiaomei; DONG, Xu; CHEN, Yichong; LI, Junjie; et al. (Chinese journal of natural medicines, 2024)
Keywords: Animals; cGAS-STING pathway; Glucosides - pharmacology; Humans; Inflammation; Interferon Regulatory Factor-3 - metabolism; LPS/D-GalN; Macrophages - drug effects; Macrophages - metabolism; Membrane Proteins - genetics; Membrane Proteins - metabolism; Mice; Mice, Inbred C57BL; Nucleotidyltransferases - genetics; Nucleotidyltransferases - metabolism; Paeonia - chemistry; Signal Transduction - drug effects; STING inhibitor; THP-1 Cells; Total glucosides of gaeony; LPS/D-GalN; Inflammation; STING inhibitor; Total glucosides of gaeony; cGAS-STING pathway