Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies

• Published in: Developmental cell Vol. 60; no. 15; pp. 2114 - 2130.e9
• Main Authors: Yeat, Nai Yang, Liu, Li-Heng, Chang, Yu-Hsuan, Lai, Charles Pin-Kuang, Chen, Ruey-Hwa
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.08.2025
• Subjects: actin cytoskeletons; Actins - metabolism; Animals; Calcium-Binding Proteins; CapZ Actin Capping Protein; Cell Cycle Proteins; Cell Line; endocytic trafficking; Endosomal Sorting Complexes Required for Transport; ESCRT complex; exosome biogenesis; Exosomes; GTP-Binding Proteins - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Nude; Multivesicular Bodies - physiology; multivesicular body; Neoplasm Metastasis; Neoplasms, Experimental - pathology; Protein Tyrosine Phosphatases, Non-Receptor - metabolism; Tumor Escape; tumor microenvironment; actin cytoskeletons; exosome biogenesis; endocytic trafficking; tumor microenvironment; ESCRT complex; multivesicular body

Exosomes play pleiotropic tumor-promoting functions and are secreted by fusion of multivesicular bodies (MVBs) with the plasma membrane. However, MVBs are also directed to lysosomes for degradation, and the mechanism controlling different fates of MVBs remains elusive. Here, we show that the pro-tum...