Bro1 proteins determine tumor immune evasion and metastasis by controlling secretion or degradation of multivesicular bodies - Yeat, Nai Yang; Liu, Li-Heng; Chang, Yu-Hsuan; Lai, Charles Pin-Kuang; Chen, Ruey-Hwa (Developmental cell, 2025)
Keywords: actin cytoskeletons; Actins - metabolism; Animals; Calcium-Binding Proteins; CapZ Actin Capping Protein; Cell Cycle Proteins; Cell Line; endocytic trafficking; Endosomal Sorting Complexes Required for Transport; ESCRT complex; exosome biogenesis; Exosomes; GTP-Binding Proteins - metabolism; Humans; Male; Mice; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Nude; Multivesicular Bodies - physiology; multivesicular body; Neoplasm Metastasis; Neoplasms, Experimental - pathology; Protein Tyrosine Phosphatases, Non-Receptor - metabolism; Tumor Escape; tumor microenvironment; actin cytoskeletons; exosome biogenesis; endocytic trafficking; tumor microenvironment; ESCRT complex; multivesicular body