Inhibition of phosphodiesterase 4 and 7 regulates breast cancer cell proliferation

• Published in: Biochimica et biophysica acta. General subjects Vol. 1869; no. 11; p. 130850
• Main Authors: Mayora Justel, Carla, Valladares, Tamara, Gargiulo, Lucía, González-Pardo, Verónica, De Sousa, Maximiliano, Esandi, María del Carmen, Davio, Carlos, Lüthy, Isabel, Bruzzone, Ariana
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2025
• Subjects: Breast neoplasm; Cell line; Cyclic AMP; Gene expression; Phosphodiesterase 4 inhibitor; Roflumilast; Cyclic AMP; Cell line; Roflumilast; Phosphodiesterase 4 inhibitor; Gene expression; Breast neoplasm

cAMP regulates key processes in mammary cell biology. Previous studies suggested reduced cAMP production in more malignant cells. This study investigates the role of cAMP in mammary biology using non-tumor (MCF-10A  and HBL-100) and tumor (MCF-7 and MDA-MB-231) human breast cell lines. cAMP levels w...