Preparation and physicochemical characterization of a solid dispersion of (3, 5, 6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3, 5, 6-trimethylpyrazin-2-yl) methoxy] benzoate (VA-T) and polyvinylpyrrolidone

• Published in: Chinese journal of natural medicines Vol. 13; no. 11; pp. 861 - 866
• Main Authors: CAO, Sa-Li, HOU, Peng, LI, Bin, FU, Jing, YIN, Xing-Bin, DANG, Xiao-Fang, YANG, Chun-Jing, ZHANG, Jin, ZHANG, Hui, LEI, Hai-Min, NI, Jian
• Format: Journal Article
• Language: English
• Published: China Elsevier B.V 01.11.2015
• Subjects: Benzoates - administration & dosage; Benzoates - chemistry; Brain Ischemia - drug therapy; Chemistry, Pharmaceutical - methods; Dissolution; Drug Delivery Systems; Ischemic stroke; Physicochemical characterization; Povidone - chemistry; Solid dispersions; Solubility; VA-T; Physicochemical characterization; Solid dispersions; VA-T; Ischemic stroke; Dissolution

Ischemic brain injury is a major disease which threatens human health and safety. (3, 5, 6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3, 5, 6-trimethylpyrazin-2-yl) methoxy] benzoate (VA-T), a newly discovered lead compound, is effective for the treatment of ischemic brain injury and its sequelae....