Epidemiology of thyroid-stimulating immunoglobulin in recent-onset symptomatic thyroid eye disease
Purpose This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset symptomatic thyroid eye disease (TED) patients. Methods A prospective cohort study of TED patients managed at the Chinese University of Hong K...
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Published in | European thyroid journal Vol. 13; no. 4; pp. 1 - 7 |
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Abstract | Purpose This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset symptomatic thyroid eye disease (TED) patients. Methods A prospective cohort study of TED patients managed at the Chinese University of Hong Kong from January 2014 to May 2022. Serum TSI levels were determined with the functional assay. Outcomes included the Clinical Activity Score (CAS), marginal reflex distance1 (MRD1), extraocular muscle motility restriction (EOMy), exophthalmos, and diplopia. The radiological assessment included cross-sectional areas and signal of extraocular muscles on STIR-sequence MRI. Results A total of 255 (197 female) treatment-naive patients, with an average onset age of 50 ± 14 years (mean ± s.d. ), were included. Elevated pre-treatment TSI level was observed in 223 (88%) patients. There was a weak positive correlation between TSI and CAS ( r = 0.28, P = 0.000031), MRD1 ( r = 0.17, P = 0.0080), and the size of the levator palpebrae superioris/superior rectus complex ( r = 0.25, P = 0.018). No significant correlation existed between TSI and STIR signals. The AUC and optimal cut-off value for clinical active TED were 0.67 (95% CI: 0.60–0.75) and 284% (specificity: 50%, sensitivity: 85%). In total, 64 patients received intravenous methylprednisolone (IVMP) during the study interval, and they had a higher baseline TSI level than those who did not have IVMP ( P = 0.000044). Serial post-IVMP TSI among the 62 patients showed a significant reduction compared to the baseline level ( P < 0.001). Both the baseline and post-IVMP TSI levels, and percentages of TSI changes were comparable between patients who responded and did not respond to the first course of IVMP. Conclusion TSI can be a serum biomarker for the diagnosis, prognosis, and treatment response of TED. Further validation should be warranted. |
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AbstractList | Purpose: This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset symptomatic thyroid eye disease (TED) patients. Methods: A prospective cohort study of TED patients managed at the Chinese University of Hong Kong from January 2014 to May 2022. Serum TSI levels were determined with the functional assay. Outcomes included the Clinical Activity Score (CAS), marginal reflex distance1 (MRD1), extraocular muscle motility restriction (EOMy), exophthalmos, and diplopia. The radiological assessment included cross-sectional areas and signal of extraocular muscles on STIR-sequence MRI. Results: A total of 255 (197 female) treatment-naive patients, with an average onset age of 50 ± 14 years (mean ± s.d.), were included. Elevated pre-treatment TSI level was observed in 223 (88%) patients. There was a weak positive correlation between TSI and CAS (r = 0.28, P = 0.000031), MRD1 (r = 0.17, P = 0.0080), and the size of the levator palpebrae superioris/superior rectus complex (r = 0.25, P = 0.018). No significant correlation existed between TSI and STIR signals. The AUC and optimal cut-off value for clinical active TED were 0.67 (95% CI: 0.60–0.75) and 284% (specificity: 50%, sensitivity: 85%). In total, 64 patients received intravenous methylprednisolone (IVMP) during the study interval, and they had a higher baseline TSI level than those who did not have IVMP (P = 0.000044). Serial post-IVMP TSI among the 62 patients showed a significant reduction compared to the baseline level (P < 0.001). Both the baseline and post-IVMP TSI levels, and percentages of TSI changes were comparable between patients who responded and did not respond to the first course of IVMP. Conclusion: TSI can be a serum biomarker for the diagnosis, prognosis, and treatment response of TED. Further validation should be warranted. This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset symptomatic thyroid eye disease (TED) patients.PurposeThis study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset symptomatic thyroid eye disease (TED) patients.A prospective cohort study of TED patients managed at the Chinese University of Hong Kong from January 2014 to May 2022. Serum TSI levels were determined with the functional assay. Outcomes included the Clinical Activity Score (CAS), marginal reflex distance1 (MRD1), extraocular muscle motility restriction (EOMy), exophthalmos, and diplopia. The radiological assessment included cross-sectional areas and signal of extraocular muscles on STIR-sequence MRI.MethodsA prospective cohort study of TED patients managed at the Chinese University of Hong Kong from January 2014 to May 2022. Serum TSI levels were determined with the functional assay. Outcomes included the Clinical Activity Score (CAS), marginal reflex distance1 (MRD1), extraocular muscle motility restriction (EOMy), exophthalmos, and diplopia. The radiological assessment included cross-sectional areas and signal of extraocular muscles on STIR-sequence MRI.A total of 255 (197 female) treatment-naive patients, with an average onset age of 50 ± 14 years (mean ± s.d.), were included. Elevated pre-treatment TSI level was observed in 223 (88%) patients. There was a weak positive correlation between TSI and CAS (r = 0.28, P = 0.000031), MRD1 (r = 0.17, P = 0.0080), and the size of the levator palpebrae superioris/superior rectus complex (r = 0.25, P = 0.018). No significant correlation existed between TSI and STIR signals. The AUC and optimal cut-off value for clinical active TED were 0.67 (95% CI: 0.60-0.75) and 284% (specificity: 50%, sensitivity: 85%). In total, 64 patients received intravenous methylprednisolone (IVMP) during the study interval, and they had a higher baseline TSI level than those who did not have IVMP (P = 0.000044). Serial post-IVMP TSI among the 62 patients showed a significant reduction compared to the baseline level (P < 0.001). Both the baseline and post-IVMP TSI levels, and percentages of TSI changes were comparable between patients who responded and did not respond to the first course of IVMP.ResultsA total of 255 (197 female) treatment-naive patients, with an average onset age of 50 ± 14 years (mean ± s.d.), were included. Elevated pre-treatment TSI level was observed in 223 (88%) patients. There was a weak positive correlation between TSI and CAS (r = 0.28, P = 0.000031), MRD1 (r = 0.17, P = 0.0080), and the size of the levator palpebrae superioris/superior rectus complex (r = 0.25, P = 0.018). No significant correlation existed between TSI and STIR signals. The AUC and optimal cut-off value for clinical active TED were 0.67 (95% CI: 0.60-0.75) and 284% (specificity: 50%, sensitivity: 85%). In total, 64 patients received intravenous methylprednisolone (IVMP) during the study interval, and they had a higher baseline TSI level than those who did not have IVMP (P = 0.000044). Serial post-IVMP TSI among the 62 patients showed a significant reduction compared to the baseline level (P < 0.001). Both the baseline and post-IVMP TSI levels, and percentages of TSI changes were comparable between patients who responded and did not respond to the first course of IVMP.TSI can be a serum biomarker for the diagnosis, prognosis, and treatment response of TED. Further validation should be warranted.ConclusionTSI can be a serum biomarker for the diagnosis, prognosis, and treatment response of TED. Further validation should be warranted. |
Author | Aljufairi, Fatema Mohamed Ali Abdulla Pang, Chi Pui Lai, Kenneth Ka Hei Wei, Yingying Jia, Ruofan Lee, Alan Chun Hong Au, Elaine Yuen Ling Yuen, Hunter Kwok Lai Ng, Chiu Ming Sebastian, Jake Uy Yip, Wilson Wai Kuen Cheng, George Pak Man Chong, Kelvin Kam Lung Tham, Clement Chee Yung Young, Alvin Lerrmann Chan, Karen Kar Wun |
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References | Eckstein (bib13) 2006; 91 Lee (bib41) 2023; 12 Zhang (bib27) 2009; 284 Wakelkamp (bib29) 2003; 58 Hoh (bib22) 1994; 8 Girnita (bib25) 2022; 107 (bib44) 2024; 44 Khong (bib7) 2016; 100 Lee (bib8) 2023; 37 Jang (bib16) 2014; 80 Lim (bib40) 2015; 99 Chong (bib20) Bartalena (bib17) 2021; 185 Hai (bib24) 2020; 43 Mourits (bib18) 1997; 47 Eckstein (bib32) 2010; 7 Barbesino (bib9) 2013; 98 Kahaly (bib10) 2017; 8 Jang (bib15) 2013; 27 Lantz (bib31) 2014; 122 Bluszcz (bib43) 2018; 43 Lantz (bib14) 2014; 122 Gorman (bib19) 1998; 8 Rundle (bib4) 1945; 5 Wiersinga (bib6) 1996; 15 Tabasum (bib30) 2016; 2016 Ajjan (bib11) 2008; 4 Noh (bib33) 2000; 10 Rundle (bib5) 1957; 6 Seo (bib12) 2018; 41 Ko (bib37) 2022; 12 Ohtsuka (bib36) 2000; 84 Ponto (bib34) 2011; 118 Kumar (bib26) 2012; 97 Park (bib42) 2023; 14 Tsui (bib28) 2008; 181 Lai (bib21) 2024; 52 Khamisi (bib35) 2023; 131 Ponto (bib39) 2015; 38 Bartalena (bib1) 2014; 37 Lai (bib23) 2023; 51 Jeon (bib38) 2023; 37 Bahn (bib2) 2010; 362 |
References_xml | – volume: 41 start-page: 1457 year: 2018 ident: bib12 article-title: Usefulness of TSH receptor antibodies as biomarkers for Graves’ ophthalmopathy: a systematic review contributor: fullname: Seo – volume: 12 start-page: e050337 year: 2022 ident: bib37 article-title: Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease contributor: fullname: Ko – volume: 131 start-page: 236 year: 2023 ident: bib35 article-title: Comparison between thyroid stimulating immunoglobulin and TSH-receptor antibodies in the management of Graves’ orbitopathy contributor: fullname: Khamisi – volume: 2016 start-page: 160008 year: 2016 ident: bib30 article-title: Thyroid antibody-negative euthyroid Graves’ ophthalmopathy contributor: fullname: Tabasum – volume: 43 start-page: 123 year: 2020 ident: bib24 article-title: Immunohistochemical analysis of human orbital tissue in Graves’ orbitopathy contributor: fullname: Hai – volume: 37 start-page: 101620 year: 2023 ident: bib8 article-title: Pathophysiology of thyroid-associated orbitopathy contributor: fullname: Lee – volume: 80 start-page: 591 year: 2014 ident: bib16 article-title: Clinical characteristics of Graves’ orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay contributor: fullname: Jang – volume: 58 start-page: 280 year: 2003 ident: bib29 article-title: TSH-R expression and cytokine profile in orbital tissue of active vs. inactive Graves’ ophthalmopathy patients contributor: fullname: Wakelkamp – volume: 43 start-page: 405 year: 2018 ident: bib43 article-title: Clinical utility of TSH receptor antibody levels in Graves' orbitopathy: a comparison of two TSH receptor antibody immunoassays contributor: fullname: Bluszcz – volume: 44 start-page: 124 year: 2024 ident: bib44 article-title: Ocular surface and meibomian gland evaluation in euthyroid Graves’ ophthalmopathy – volume: 10 start-page: 809 year: 2000 ident: bib33 article-title: Thyroid-stimulating antibody is related to Graves’ ophthalmopathy, but thyrotropin-binding inhibitor immunoglobulin is related to hyperthyroidism in patients with Graves’ disease contributor: fullname: Noh – volume: 185 start-page: G43 year: 2021 ident: bib17 article-title: The 2021 European Group on Graves’ orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves’ orbitopathy contributor: fullname: Bartalena – volume: 14 start-page: 1153312 year: 2023 ident: bib42 article-title: Prognostic significance of thyroid-stimulating hormone receptor antibodies in moderate-to-severe graves’ orbitopathy contributor: fullname: Park – volume: 122 start-page: 113 year: 2014 ident: bib14 article-title: Increased TRAb and/or low anti-TPO titers at diagnosis of Graves’ disease are associated with an increased risk of developing ophthalmopathy after onset contributor: fullname: Lantz – volume: 7 start-page: 198 issue: Supplement 2 year: 2010 ident: bib32 article-title: Clinical value of TSH receptor antibodies measurement in patients with Graves’ orbitopathy contributor: fullname: Eckstein – volume: 37 start-page: 691 year: 2014 ident: bib1 article-title: Extrathyroidal manifestations of Graves’ disease: a 2014 update contributor: fullname: Bartalena – volume: 181 start-page: 4397 year: 2008 ident: bib28 article-title: Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves’ disease contributor: fullname: Tsui – volume: 5 start-page: 177 year: 1945 ident: bib4 article-title: Development and course of exophthalmos and ophthalmoplegia in Graves’ disease with special reference to the effect of thyroidectomy contributor: fullname: Rundle – volume: 362 start-page: 726 year: 2010 ident: bib2 article-title: Graves’ ophthalmopathy contributor: fullname: Bahn – volume: 8 start-page: 539 year: 1998 ident: bib19 article-title: The measurement of change in Graves’ ophthalmopathy contributor: fullname: Gorman – volume: 122 start-page: 113 year: 2014 ident: bib31 article-title: Increased TRAb and/or low anti-TPO titers at diagnosis of Graves’ disease are associated with an increased risk of developing ophthalmopathy after onset contributor: fullname: Lantz – volume: 37 start-page: 543 year: 2023 ident: bib38 article-title: Clinical relevance of thyroid-stimulating immunoglobulin as a biomarker of the activity of thyroid eye disease contributor: fullname: Jeon – volume: 51 start-page: 878 year: 2023 ident: bib23 article-title: Sirolimus versus mycophenolate mofetil for triple immunosuppression in thyroid eye disease patients with recent-onset intractable diplopia: a prospective comparative case series contributor: fullname: Lai – volume: 84 start-page: 103 year: 2000 ident: bib36 article-title: Serum levels of soluble Fas in patients with Graves’ ophthalmopathy contributor: fullname: Ohtsuka – volume: 97 start-page: 1681 year: 2012 ident: bib26 article-title: A stimulatory thyrotropin receptor antibody enhances hyaluronic acid synthesis in Graves’ orbital fibroblasts: inhibition by an IGF-I receptor blocking antibody contributor: fullname: Kumar – volume: 118 start-page: 2279 year: 2011 ident: bib34 article-title: Clinical relevance of thyroid-stimulating immunoglobulins in graves’ ophthalmopathy contributor: fullname: Ponto – volume: 100 start-page: 142 year: 2016 ident: bib7 article-title: Pathogenesis of thyroid eye disease: review and update on molecular mechanisms contributor: fullname: Khong – volume: 8 start-page: 506 year: 1994 ident: bib22 article-title: The STIR sequence MRI in the assessment of extraocular muscles in thyroid eye disease contributor: fullname: Hoh – volume: 98 start-page: 2247 year: 2013 ident: bib9 article-title: Clinical review: clinical utility of TSH receptor antibodies contributor: fullname: Barbesino – volume: 91 start-page: 3464 year: 2006 ident: bib13 article-title: Thyrotropin receptor autoantibodies are independent risk factors for Graves’ ophthalmopathy and help to predict severity and outcome of the disease contributor: fullname: Eckstein – volume: 38 start-page: 769 year: 2015 ident: bib39 article-title: Thyroid-stimulating immunoglobulins indicate the onset of dysthyroid optic neuropathy contributor: fullname: Ponto – volume: 47 start-page: 9 year: 1997 ident: bib18 article-title: Clinical activity score as a guide in the management of patients with Graves’ ophthalmopathy contributor: fullname: Mourits – volume: 12 start-page: 1851 year: 2023 ident: bib41 article-title: Changes in clinical activity, serum autoantibody levels, and chorioretinal vessels after systemic glucocorticoid therapy in thyroid eye disease contributor: fullname: Lee – volume: 8 start-page: 28 year: 2017 ident: bib10 article-title: TSH receptor antibody functionality and nomenclature contributor: fullname: Kahaly – volume: 107 start-page: S1 issue: Supplement 1 year: 2022 ident: bib25 article-title: It takes two to tango: IGF-I and TSH receptors in thyroid eye disease contributor: fullname: Girnita – volume: 99 start-page: 512 year: 2015 ident: bib40 article-title: Thyroid eye disease: a Southeast Asian experience contributor: fullname: Lim – volume: 6 start-page: 36 year: 1957 ident: bib5 article-title: Management of exophthalmos and related ocular changes in Graves’ disease contributor: fullname: Rundle – volume: 4 start-page: 46 year: 2008 ident: bib11 article-title: Techniques to quantify TSH receptor antibodies contributor: fullname: Ajjan – volume: 52 start-page: 115 year: 2024 ident: bib21 article-title: Paediatric-onset versus adult-onset thyroid eye disease: difference in clinical presentations contributor: fullname: Lai – volume: 15 start-page: 177 year: 1996 ident: bib6 article-title: Advances in medical therapy of thyroid-associated ophthalmopathy contributor: fullname: Wiersinga – volume: 27 start-page: 964 year: 2013 ident: bib15 article-title: Relevance of TSH-receptor antibody levels in predicting disease course in Graves’ orbitopathy: comparison of the third-generation TBII assay and Mc4-TSI bioassay contributor: fullname: Jang – ident: bib20 article-title: Comparing the clinical characteristics of muscle predominant versus fat predominant manifestation in thyroid eye Disease (TED). (Conference presentation abstract) contributor: fullname: Chong – volume: 284 start-page: 26447 year: 2009 ident: bib27 article-title: Thyrotropin receptor activation increases hyaluronan production in preadipocyte fibroblasts: contributory role in hyaluronan accumulation in thyroid dysfunction contributor: fullname: Zhang |
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Snippet | Purpose This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset... This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset... Purpose: This study aims to report correlations between thyroid-stimulating immunoglobulin (TSI) and both clinical and radiological parameters in recent-onset... |
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Title | Epidemiology of thyroid-stimulating immunoglobulin in recent-onset symptomatic thyroid eye disease |
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