Dearomatization of 3‐Nitroindoles by a Phosphine‐Catalyzed Enantioselective [3+2] Annulation Reaction

• Published in: Angewandte Chemie Vol. 131; no. 16; pp. 5481 - 5485
• Main Authors: Li, Kaizhi, Gonçalves, Théo P., Huang, Kuo‐Wei, Lu, Yixin
• Format: Journal Article
• Language: English
• Published: Weinheim Wiley Subscription Services, Inc 08.04.2019
• Subjects: [3+2]-Anellierung; Chemical reactions; Chemistry; Cyclopentaindoline; Dearomatisierung; Enantiomers; Nitroindole; Organic chemistry; Organokatalyse; Phosphine

The dearomatization of 3‐nitroindoles through a chiral‐phosphine‐mediated [3+2] annulation reaction is described. This method makes use of readily available 3‐nitroindoles as an aromatic feedstock and rapidly delivers a wide range of cyclopentaindoline alkaloid scaffolds in a highly enantioselective...