Association of the TNF‐α‐308G>A gene polymorphism with left ventricular geometry and functional abnormalities in obstructive sleep apnea subjects

• Published in: Journal of clinical ultrasound Vol. 52; no. 3; pp. 241 - 248
• Main Authors: Chen, Shuqiong, Wang, Jian, Shui, Wen, Xing, Xueqing, Zhang, Zhenxia, Hou, Ran
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.03.2024; Wiley Subscription Services, Inc
• Subjects: Abnormalities; Apnea; Echocardiography; Gene polymorphism; Genetic analysis; Geometry; Heart; Hypertrophy; left ventricular geometry; obstructive sleep apnea; Polymorphism; Regression analysis; Single-nucleotide polymorphism; Sleep apnea; Sleep disorders; Tumor necrosis factor; Tumor necrosis factor-TNF; tumor necrosis factor‐α; Ventricle; obstructive sleep apnea; gene polymorphism; left ventricular geometry; tumor necrosis factor-α; echocardiography

Objective Tumor necrosis factor‐α (TNF‐α) can induce left ventricular remodeling. In this study, we investigated whether the TNF‐α‐308G>A polymorphism is associated with left ventricular geometry (LVG) and left ventricular functional abnormalities in obstructive sleep apnea (OSA) subjects. Method...