Abrogation of glucocorticoid-mediated inhibition of T cell proliferation by the synergistic action of IL-1, IL-6, and IFN-gamma

• Published in: The Journal of immunology (1950) Vol. 146; no. 10; pp. 3523 - 3527
• Main Authors: Almawi, WY, Lipman, ML, Stevens, AC, Zanker, B, Hadro, ET, Strom, TB
• Format: Journal Article
• Language: English
• Published: United States Am Assoc Immnol 15.05.1991
• Subjects: Cells, Cultured; Dexamethasone - pharmacology; Drug Synergism; Humans; Interferon-gamma - pharmacology; Interleukin-1 - pharmacology; Interleukin-2 - genetics; Interleukin-6 - pharmacology; Lymphocyte Activation - drug effects; Recombinant Proteins - pharmacology; T-Lymphocytes - drug effects; T-Lymphocytes - immunology; Transcription, Genetic - drug effects

Glucocorticoids (GCS) inhibit the transcription of multiple activation-associated cytokine genes. By Northern blot analysis now we demonstrate that antiproliferative concentrations of dexamethasone and 6 alpha-methylprednisolone block mitogen-induced IL-2 gene expression in human peripheral blood mo...