Irigenin Alleviates Blue Light‐Induced Retinal Damage by Upregulating Antioxidative Defense System via Nrf2 Pathway In Vivo and In Vitro

• Published in: Environmental toxicology Vol. 40; no. 8; pp. 1072 - 1086
• Main Authors: Yeh, Kun‐Lin, Kuan, Yu‐Hsiang, Wu, Sheng‐Wen, Chiang, Chen‐Yu, Chen, Chun‐Jung, Chen, Wen‐Ying, Chou, Chi‐Chung
• Format: Journal Article
• Language: English
• Published: Hoboken, USA John Wiley & Sons, Inc 01.08.2025; Wiley Subscription Services, Inc
• Subjects: Animals; Antioxidants - metabolism; Antioxidants - pharmacology; antioxidative defense system; Apoptosis; Apoptosis - drug effects; Biocompatibility; Blue Light; Caspase; Catalase; Cell Line; Cell Survival - drug effects; Cell viability; Cells; Cytochrome; Cytochrome c; Cytochromes; Cytotoxicity; DA50062; Damage; Exposure; Flow cytometry; Glutathione; Glutathione peroxidase; Heme oxygenase (decyclizing); Humans; irigenin; Light - adverse effects; Lipid peroxidation; Lipids; Male; Membrane potential; Mice; Molecular modelling; NF-E2-Related Factor 2 - metabolism; Oxidative Stress - drug effects; Peroxidase; Peroxidation; Reactive oxygen species; Reactive Oxygen Species - metabolism; Retina; Retina - drug effects; Retina - radiation effects; retinal pigment epithelial cell; Retinal Pigment Epithelium - drug effects; Signal Transduction - drug effects; Superoxide dismutase; Up-Regulation; Western blotting; DA50062; antioxidative defense system; blue light; retinal pigment epithelial cell; irigenin

ABSTRACT This research aimed to assess the potential of irigenin to attenuate blue light (BL)‐induced apoptosis in human adult retinal pigment epithelial (hARPE‐19) cells loaded with N‐retinylidene‐N‐retinylethanolamine (A2E, DA50062). Furthermore, the study investigated the associated molecular mec...