Assessment of syndecan-4 expression in the hearts of Trypanosoma cruzi-infected mice and human subjects with chronic Chagas disease cardiomyopathy

• Published in: Surgical and experimental pathology Vol. 1; no. 1; pp. 1 - 12
• Main Authors: Larocca, Ticiana Ferreira, Souza, Bruno Solano de Freitas, Macêdo, Carolina Thé, Azevedo, Carine Machado, Vasconcelos, Juliana Fraga, Silva, Daniela Nascimento, Portella, Diogo Crispim Nascimento, dos Santos, Washington Luis Conrado, Tavora, Fabio Rocha Fernandes, Souza Neto, João David de, dos Santos, Ricardo Ribeiro, Soares, Milena Botelho Pereira
• Format: Journal Article
• Language: English
• Published: London BioMed Central 10.12.2018; BMC
• Subjects: Animals; Cardiomyopathy; Chagas disease; Cybernetics; Heart failure; Heparan sulfate; Infections; Inflammation; Pathogenesis; Smooth muscle; Software; Syndecan-4; Thermal cycling; Tropical diseases; Variance analysis; United States > US

Background Chronic Chagas cardiomyopathy (CCC) is characterized by the presence of a multifocal inflammatory response and myocardial damage, leading to fibrosis, arrhythmias and ventricular dysfunction. The expression of syndecan-4, a transmembrane proteoglycan, was previously found to be increased...