The clinical significance of plasma endothelin-1 in venous and portal blood of patients with portal hypertension
To investigate the significance of endothelin-1 (ET) in the pathophysiology of portal hypertension, we measured the plasma levels of ET in venous and portal blood of 37 patients with portal hypertension by means of enzyme immunoassay. The ET levels in venous blood (ETv) in patients with liver cirrho...
Saved in:
| Published in | Kanzo Vol. 41; no. 12; pp. 789 - 798 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | Japanese |
| Published |
The Japan Society of Hepatology
2000
|
| Online Access | Get full text |
| ISSN | 0451-4203 1881-3593 |
| DOI | 10.2957/kanzo.41.789 |
Cover
| Abstract | To investigate the significance of endothelin-1 (ET) in the pathophysiology of portal hypertension, we measured the plasma levels of ET in venous and portal blood of 37 patients with portal hypertension by means of enzyme immunoassay. The ET levels in venous blood (ETv) in patients with liver cirrhosis (LC, n=16), idiopathic portal hypertension (IPH, n=13) and primary biliary cirrhosis (PBC, n=8) were higher than those in healthy subjects. The ET levels in portal blood (ETp) in patients with IPH were significantly lower than those in patients with LC and PBC. No correlation between the levels of ETv or ETp and values of portal vein pressure (PVP) was noted in any kinds of diseases. ETp values correlated with total bilirubin values in LC patients, whereas ETv and ETp values correlated with indocyanine green dye retention rate at 15 minutes values in PBC patients. After endoscopic injection sclerotherapy (EIS) of esophagogastric varices, both ETp levels and PVP values were decreased in 4 of 6 LC patients, whereas both ETp levels and PVP values were increased in 2 of 3 PBC patients. These results suggest that ETp might play some roles in the pathophysiology of portal hypertension. |
|---|---|
| AbstractList | To investigate the significance of endothelin-1 (ET) in the pathophysiology of portal hypertension, we measured the plasma levels of ET in venous and portal blood of 37 patients with portal hypertension by means of enzyme immunoassay. The ET levels in venous blood (ETv) in patients with liver cirrhosis (LC, n=16), idiopathic portal hypertension (IPH, n=13) and primary biliary cirrhosis (PBC, n=8) were higher than those in healthy subjects. The ET levels in portal blood (ETp) in patients with IPH were significantly lower than those in patients with LC and PBC. No correlation between the levels of ETv or ETp and values of portal vein pressure (PVP) was noted in any kinds of diseases. ETp values correlated with total bilirubin values in LC patients, whereas ETv and ETp values correlated with indocyanine green dye retention rate at 15 minutes values in PBC patients. After endoscopic injection sclerotherapy (EIS) of esophagogastric varices, both ETp levels and PVP values were decreased in 4 of 6 LC patients, whereas both ETp levels and PVP values were increased in 2 of 3 PBC patients. These results suggest that ETp might play some roles in the pathophysiology of portal hypertension. |
| Author | OHIRA, Hiromasa KAISE, Shunji KOJIMA, Toshihiko OBARA, Katsutoshi TAKAGI, Tohru KASUKAWA, Reiji KURODA, Masahito |
| Author_xml | – sequence: 1 fullname: KURODA, Masahito organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: KOJIMA, Toshihiko organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: KAISE, Shunji organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: OHIRA, Hiromasa organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: OBARA, Katsutoshi organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: TAKAGI, Tohru organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine – sequence: 1 fullname: KASUKAWA, Reiji organization: Department of Internal Medicine II, Fukushima Medical University School of Medicine |
| BookMark | eNo9kMtOwzAQRS1UJErpjg_wB5DiRxzbS1RBQarEpqwjx7EbQ2pHtgGVrye0pZuZke45s7jXYOKDNwDcYrQgkvH7D-V_wqLECy7kBZhiIXBBmaQTMEUlw0VJEL0C85RcgxCpOJKSTMGw6QzUvfNOqx4mt_XOjqfXBgYLh16lnYLGtyF3ZqQKDJ2HX8aHzwSVb-EQYh7Fpg-hPRgqO-Nzgt8ud_9ptx9MzMYnF_wNuLSqT2Z-2jPw9vS4WT4X69fVy_JhXWhCqlxYwUpJkECaScQlZ8qylrSoUahBgmLRaI6t4IwJg6msOGENp1gapgQpraQzcHf8q2NIKRpbD9HtVNzXGNV_hdWHwuoS12NhI7464u8pq605wypmp3tzhLGs0J-AyWmO5pnQnYq18fQX0_Z7Sg |
| ContentType | Journal Article |
| Copyright | The Japan Society of Hepatology |
| Copyright_xml | – notice: The Japan Society of Hepatology |
| DBID | AAYXX CITATION |
| DOI | 10.2957/kanzo.41.789 |
| DatabaseName | CrossRef |
| DatabaseTitle | CrossRef |
| DatabaseTitleList | |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1881-3593 |
| EndPage | 798 |
| ExternalDocumentID | 10_2957_kanzo_41_789 article_kanzo1960_41_12_41_12_789_article_char_en |
| GroupedDBID | ALMA_UNASSIGNED_HOLDINGS CS3 JSF KQ8 P2P RJT 2WC AAYXX CITATION OK1 |
| ID | FETCH-LOGICAL-c226t-f85492080c5907975af5d2d0ba0b08318bc71f87558e1396725b7319e5a824f93 |
| ISSN | 0451-4203 |
| IngestDate | Tue Jul 01 01:58:57 EDT 2025 Wed Sep 03 06:08:59 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 12 |
| Language | Japanese |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c226t-f85492080c5907975af5d2d0ba0b08318bc71f87558e1396725b7319e5a824f93 |
| OpenAccessLink | https://www.jstage.jst.go.jp/article/kanzo1960/41/12/41_12_789/_article/-char/en |
| PageCount | 10 |
| ParticipantIDs | crossref_primary_10_2957_kanzo_41_789 jstage_primary_article_kanzo1960_41_12_41_12_789_article_char_en |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2000-00-00 |
| PublicationDateYYYYMMDD | 2000-01-01 |
| PublicationDate_xml | – year: 2000 text: 2000-00-00 |
| PublicationDecade | 2000 |
| PublicationTitle | Kanzo |
| PublicationTitleAlternate | Kanzo |
| PublicationYear | 2000 |
| Publisher | The Japan Society of Hepatology |
| Publisher_xml | – name: The Japan Society of Hepatology |
| References | 11) 小原勝敏, 正木盛夫, 坂本弘明, 他: 食道・胃静脈瘤硬化療法におけるEO単独およびEO・AS併用法からみた予後の検討. Gastroenterol. Endosc. 29: 2232-2236, 1987 16) Rieder H, Ramadori G, Meyer KH,: Sinusoidal endothelial liver cells in vitro release endothelin-Augmentation by transforming growth factor β and kupffer cellconditioned media. Klin Wochenschr 69: 387-391, 1991 3) Luscher TF, Tanner FC: Endothelial regulation of vascular tone and growth. Am J Hypertens 6: 283-293, 1993 24) Namiki A, Hirata Y, Ishikawa M,: Endothelin-1 and endothelin-3 induced vasorelaxation via common generation of endothelium-derived nitric oxide. Life Sci 50: 677-682, 1992 7) Gandhi C. R, Stephenson K, Olson M. S,: Endothelin, a potent peptide agonist in the liver. J Biol Chem 265: 17432-17435, 1990 13) 成瀬光栄, 大隈一興, 成瀬清子, 他: 血中エンドセリンのラジオイムノアッセイに関する基礎的, 臨床的検討. エンドセリンー最新情報, 平田結喜緒, 柳沢正史編, 中外医学社, 東京, 1990, p171-174 19) 竹井謙之, 後藤守孝, 福井弘幸, 他: 肝微小循環-最近の話題-. 最新医学46: 73-80, 1991 27) Toyonaga A, Iwao T, Sumino M,: Portal pressure after prophylactic sclerotherapy in patients with high-risk varices. J Hepatol 21: 515-520, 1994 4) Moller S, Henriksen JH: Endothelins in chronic liver disease. Scand J Clin Lab Invest 56: 481-490, 1996 25) 正木盛夫, 三橋彦也, 近藤祐一郎, 他: 食道静脈瘤栓塞剤 (Ethanolamine oleate; EO) の作用機序に関する研究-内皮細胞障害作用. 日消誌81: 1491, 1984 18) Bluhm RE, Frazer MG, Vore M,: Endothelin 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine. Hepatology 18: 961-968, 1993 14) Veglio F, Pinna G, Melchio R,: Plasma endothelin levels in cirrhotic subjects. J Hepatol 15: 85-87, 1992 26) 折笠和栄: 食道静脈瘤硬化剤 (Ethanolamine oleate, Aethoxysklerolおよび純エタノール) の血管内皮細胞障害機序に関する研究. 日消誌86: 2365-2372, 1989 2) Yanagisawa M, Kurihara H, Kimura S,: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988 28) 平田結喜緒: エンドセリン拮抗薬の臨床応用の可能性. 呼と循44: 1009-1017, 1996 22) 中沼安二, 太田五六: 原発性胆汁性肝硬変と門脈圧亢進: その成因に関する組織計測学的研究と他の慢性肝疾患との対比. 肝臓20: 54-61, 1979 6) Isobe H, Satoh M, Sakai H,: Increased plasma endothelin-1 levels in patients with cirrhosis and esophageal varices. J Clin Gastroenterol 17: 227-230, 1993 8) Gondo K, Ueno T, Sakamoto M,: The endothelin-1 binding site in rat liver tissue: light-and electron-microscopic autoradiographic studies. Gastroenterology 104: 1745-1749, 1993 17) Pinzani M, Milani S, Defranco R,: Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110: 534-548, 1996 15) Uchihara M, Izumi N, Sato C,: Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis. Hepatology 16: 95-99, 1992 12) 小原勝敏, 入沢篤志, 小島俊彦, 他: 孤立性胃静脈瘤にはこれだ瞬間接着剤cyanoacrylate. 消化器内視鏡7: 43-53, 1995 23) 笠井保志, 原田明生, 高木弘: エンドトキシン門脈内注入による特発性門脈圧亢進症 (IPH) 類似肝病変の作製. 肝臓31: 86-92, 1990 1) Vane J: Control of the circulation by endothelial mediators. Int Arch Allergy Immunol 101: 333-345, 1993 9) Sakamoto M, Ueno T, Kin M,: Ito cell contraction in response to endothelin-1 and substance P. Hepatology 18: 978-983, 1993 10) Martinet JP, Legault L, Cernacek P,: Changes in plasma endothelin-1 and big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites. J Hepatol 25: 700-706, 1996 5) Asbert M, Gines A, Gines P,: Circulating levels of endothelin in cirrhosis. Gastroenterology 104: 1485-1491, 1993 20) 須田陽子: 原発性胆汁性肝硬変における食道静脈瘤の特異性に関する臨床的研究. 新潟医誌102: 344-352, 1988 21) Kew MC, Varma RR, Dos Santos HA,: Portal hypertension in primary biliary cirrhosis. Gut 12: 830-834, 1971 |
| References_xml | – reference: 6) Isobe H, Satoh M, Sakai H,: Increased plasma endothelin-1 levels in patients with cirrhosis and esophageal varices. J Clin Gastroenterol 17: 227-230, 1993 – reference: 13) 成瀬光栄, 大隈一興, 成瀬清子, 他: 血中エンドセリンのラジオイムノアッセイに関する基礎的, 臨床的検討. エンドセリンー最新情報, 平田結喜緒, 柳沢正史編, 中外医学社, 東京, 1990, p171-174 – reference: 2) Yanagisawa M, Kurihara H, Kimura S,: A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature 332: 411-415, 1988 – reference: 24) Namiki A, Hirata Y, Ishikawa M,: Endothelin-1 and endothelin-3 induced vasorelaxation via common generation of endothelium-derived nitric oxide. Life Sci 50: 677-682, 1992 – reference: 11) 小原勝敏, 正木盛夫, 坂本弘明, 他: 食道・胃静脈瘤硬化療法におけるEO単独およびEO・AS併用法からみた予後の検討. Gastroenterol. Endosc. 29: 2232-2236, 1987 – reference: 18) Bluhm RE, Frazer MG, Vore M,: Endothelin 1 and 3: Potent cholestatic agents secreted and excreted by the liver that interact with cyclosporine. Hepatology 18: 961-968, 1993 – reference: 4) Moller S, Henriksen JH: Endothelins in chronic liver disease. Scand J Clin Lab Invest 56: 481-490, 1996 – reference: 10) Martinet JP, Legault L, Cernacek P,: Changes in plasma endothelin-1 and big endothelin-1 induced by transjugular intrahepatic portosystemic shunts in patients with cirrhosis and refractory ascites. J Hepatol 25: 700-706, 1996 – reference: 27) Toyonaga A, Iwao T, Sumino M,: Portal pressure after prophylactic sclerotherapy in patients with high-risk varices. J Hepatol 21: 515-520, 1994 – reference: 12) 小原勝敏, 入沢篤志, 小島俊彦, 他: 孤立性胃静脈瘤にはこれだ瞬間接着剤cyanoacrylate. 消化器内視鏡7: 43-53, 1995 – reference: 15) Uchihara M, Izumi N, Sato C,: Clinical significance of elevated plasma endothelin concentration in patients with cirrhosis. Hepatology 16: 95-99, 1992 – reference: 20) 須田陽子: 原発性胆汁性肝硬変における食道静脈瘤の特異性に関する臨床的研究. 新潟医誌102: 344-352, 1988 – reference: 8) Gondo K, Ueno T, Sakamoto M,: The endothelin-1 binding site in rat liver tissue: light-and electron-microscopic autoradiographic studies. Gastroenterology 104: 1745-1749, 1993 – reference: 21) Kew MC, Varma RR, Dos Santos HA,: Portal hypertension in primary biliary cirrhosis. Gut 12: 830-834, 1971 – reference: 5) Asbert M, Gines A, Gines P,: Circulating levels of endothelin in cirrhosis. Gastroenterology 104: 1485-1491, 1993 – reference: 23) 笠井保志, 原田明生, 高木弘: エンドトキシン門脈内注入による特発性門脈圧亢進症 (IPH) 類似肝病変の作製. 肝臓31: 86-92, 1990 – reference: 1) Vane J: Control of the circulation by endothelial mediators. Int Arch Allergy Immunol 101: 333-345, 1993 – reference: 19) 竹井謙之, 後藤守孝, 福井弘幸, 他: 肝微小循環-最近の話題-. 最新医学46: 73-80, 1991 – reference: 26) 折笠和栄: 食道静脈瘤硬化剤 (Ethanolamine oleate, Aethoxysklerolおよび純エタノール) の血管内皮細胞障害機序に関する研究. 日消誌86: 2365-2372, 1989 – reference: 3) Luscher TF, Tanner FC: Endothelial regulation of vascular tone and growth. Am J Hypertens 6: 283-293, 1993 – reference: 14) Veglio F, Pinna G, Melchio R,: Plasma endothelin levels in cirrhotic subjects. J Hepatol 15: 85-87, 1992 – reference: 25) 正木盛夫, 三橋彦也, 近藤祐一郎, 他: 食道静脈瘤栓塞剤 (Ethanolamine oleate; EO) の作用機序に関する研究-内皮細胞障害作用. 日消誌81: 1491, 1984 – reference: 9) Sakamoto M, Ueno T, Kin M,: Ito cell contraction in response to endothelin-1 and substance P. Hepatology 18: 978-983, 1993 – reference: 7) Gandhi C. R, Stephenson K, Olson M. S,: Endothelin, a potent peptide agonist in the liver. J Biol Chem 265: 17432-17435, 1990 – reference: 16) Rieder H, Ramadori G, Meyer KH,: Sinusoidal endothelial liver cells in vitro release endothelin-Augmentation by transforming growth factor β and kupffer cellconditioned media. Klin Wochenschr 69: 387-391, 1991 – reference: 22) 中沼安二, 太田五六: 原発性胆汁性肝硬変と門脈圧亢進: その成因に関する組織計測学的研究と他の慢性肝疾患との対比. 肝臓20: 54-61, 1979 – reference: 28) 平田結喜緒: エンドセリン拮抗薬の臨床応用の可能性. 呼と循44: 1009-1017, 1996 – reference: 17) Pinzani M, Milani S, Defranco R,: Endothelin-1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology 110: 534-548, 1996 |
| SSID | ssib002670992 ssib000940394 ssib002670224 ssib058493441 ssj0069113 ssib005879686 ssib002484534 |
| Score | 1.5171663 |
| Snippet | To investigate the significance of endothelin-1 (ET) in the pathophysiology of portal hypertension, we measured the plasma levels of ET in venous and portal... |
| SourceID | crossref jstage |
| SourceType | Index Database Publisher |
| StartPage | 789 |
| Title | The clinical significance of plasma endothelin-1 in venous and portal blood of patients with portal hypertension |
| URI | https://www.jstage.jst.go.jp/article/kanzo1960/41/12/41_12_789/_article/-char/en |
| Volume | 41 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Kanzo, 2000/12/25, Vol.41(12), pp.789-798 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbKQIgXxFWMm_wATyglTuw4fqMgULtpINgm7a2KnXhNJ5KpTXngD_C3Ob4kdac9DF6iNvZJm5yvx99xzwWhN7mMK5UzFcUluKtUS7CDlYojVWqdcJUpUdoA2a_Z9JQenLGz0ehPELW06eRY_b42r-R_tArnQK8mS_YfNDtcFE7Aa9AvHEHDcLyxjrepjfV5Y-J-bA5Aa_tDr38W76qmNElWMCsiZnPjlyvKausDWOrtYtethKux6hPe_OgCHNWVDXP3CvRM9hBIZTuY628Hs6OJ1X27XtSL-mI7NJkd24jL48WmWdbDpu7HyY-JD-dYbzojNQxNZ25oWq9M9FKxszMRB6aLMvBMk9iZrsqZ1jwnUcpcP8Te9rqiVz3GksCSctdZyC_K3LWqvmrvE2GbFF-YOx5TMh6EwrLaV5a7IQgR3B8jP7fSc0rmIH0L3U44JyY29PB7wFMFjdPQD6Y5ZWnox3LDhXbei-DvapZzkW3r9AHpE6nloY4yZLDi2FCI_rG5DA3z7d6H97bDne4swX3oQw8tGzp5gO57NwZPHCYfotGyeITuHvlAjcfoEqCJe2jiEJq41dhBE4fQxHWDHTQxQBM78GELTSvhoYkNNPvREJpP0OmXzyefppFv7hEpYPxdpHNTGxD8FcVEzAVnhWZlUsayiKXpfpdLxYkGb5rlFXgpGU-Y5LBeVKzIE6pF-hTtNW1TPUNYioIC75SUKE01FzID0k00JbIkkpbJPnrbP7b5pavhMr9O-fvog3umwyz_y3azYK2KzUyS-COIDDNMjiSYpOc3_KgX6J6r6WD28l6ivW61qV4Bu-3ka4u8vwLuoLA |
| linkProvider | Colorado Alliance of Research Libraries |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+clinical+significance+of+plasma+endothelin-1+in+venous+and+portal+blood+of+patients+with+portal+hypertension&rft.jtitle=Kanzo&rft.au=KOJIMA%2C+Toshihiko&rft.au=KAISE%2C+Shunji&rft.au=OBARA%2C+Katsutoshi&rft.au=OHIRA%2C+Hiromasa&rft.date=2000&rft.issn=0451-4203&rft.eissn=1881-3593&rft.volume=41&rft.issue=12&rft.spage=789&rft.epage=798&rft_id=info:doi/10.2957%2Fkanzo.41.789&rft.externalDBID=n%2Fa&rft.externalDocID=10_2957_kanzo_41_789 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0451-4203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0451-4203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0451-4203&client=summon |