Regulation of Insulin-Gene Expression

DURING the past decade, the focus of mammalian molecular biology has evolved from the characterization of gene structure to the regulation of gene expression. In parallel, the ability to manipulate isolated DNA in vitro has led to the development of methods for the modification of the genomes of bot...

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Bibliographic Details
Published inThe New England journal of medicine Vol. 317; no. 17; pp. 1067 - 1076
Main Authors Selden, Richard F, Skośkiewicz, Marek J, Russell, Paul S, Goodman, Howard M
Format Journal Article
LanguageEnglish
Published Boston Massachusetts Medical Society 22.10.1987
Subjects
Cloning
Deoxyribonucleic acid
DNA
Gene expression
Gene therapy
Genetic engineering
Insulin
Molecular biology
Peptides
Transfer RNA
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Summary:DURING the past decade, the focus of mammalian molecular biology has evolved from the characterization of gene structure to the regulation of gene expression. In parallel, the ability to manipulate isolated DNA in vitro has led to the development of methods for the modification of the genomes of both individual cells and whole animals. These technological leaps have now made it worthwhile to consider new remedies for human genetic diseases as well as for some deficiency states that are not genetically determined. In this review, we examine the regulation of mammalian gene expression and several approaches to gene therapy, using . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJM198710223171706