Ad hoc tracing of a cohort of patients exposed to acitretine (Neotigason) on a nation-wide scale

• Published in: European journal of clinical pharmacology Vol. 42; no. 5; p. 555
• Main Authors: Stricker, B H, Barendregt, M, Herings, R M, de Jong-van den Berg, L T, Cornel, M C, de Smet, P A
• Format: Journal Article
• Language: English
• Published: Germany 01.05.1992
• Subjects: Acitretin; Adolescent; Adult; Cohort Studies; Drug Monitoring; Drug Prescriptions; Female; Follow-Up Studies; Humans; Male; Middle Aged; Netherlands; Pharmacies; Pharmacy Service, Hospital; Physicians, Family; Product Surveillance, Postmarketing; Surveys and Questionnaires; Tretinoin - adverse effects; Tretinoin - analogs & derivatives; Tretinoin - therapeutic use; Netherlands

Etretinate has been detected in the blood of women taking acitretine. Because of the proven teratogenic effects of etretinate it was decided to try to trace all users of acitretine in The Netherlands via all drug dispensing outlets (1450 community pharmacies, 95 hospital pharmacies and 636 general p...