Studies of myosin isoforms in muscle cells: single cell mechanics and gene transfer

• Published in: Clinical orthopaedics and related research no. 403 Suppl; p. S51
• Main Authors: Lutz, Gordon J, Lieber, Richard L
• Format: Journal Article
• Language: English
• Published: United States 01.10.2002
• Subjects: Animals; Contractile Proteins - physiology; Gene Transfer Techniques; Humans; Muscle, Skeletal - cytology; Myosins - metabolism; Plasmids; Protein Isoforms; Rana pipiens; Transfection

Myosin, the motor protein in skeletal muscle, is composed of two subunits, myosin heavy chain and myosin light chain. All vertebrates express a family of myosin heavy chain and myosin light chain isoforms that together are primary determinants of force, velocity, and power in muscle fibers. Therefor...