Mutagenic activity of cyclohexene and products of its chlorination
Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings ar...
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| Published in | Bulletin of experimental biology and medicine Vol. 129; no. 6; pp. 581 - 583 |
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| Main Authors | , , , , , |
| Format | Journal Article |
| Language | English |
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United States
Springer Nature B.V
01.06.2000
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| Abstract | Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs. |
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| AbstractList | Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs. Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs.Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs. Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100 strain without metabolic activation and in the micronucleus test on epithelial cells from mouse urinary bladder and colon. These findings are consistent with epidemiological data on higher incidence of urinary bladder and rectal cancers in subjects consuming chlorinated drinking water from surface water reservoirs.[PUBLICATION ABSTRACT] |
| Author | Sycheva, L. P. Zholdakova, Z. I. Polyakova, E. E. Lukmanova, N. E. Zhurkov, V. S. Akhal'tseva, L. V. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/11022256$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_1016_j_mrgentox_2013_10_002 crossref_primary_10_1093_mutage_geq066 crossref_primary_10_1016_j_mrgentox_2015_03_001 crossref_primary_10_1080_02772240701655437 |
| Cites_doi | 10.1515/REVEH.1997.12.2.81 10.1016/0165-1110(88)90008-5 |
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| References | L. N. Belov (BF02434883_CR1) 1975; 17 BF02434883_CR3 BF02434883_CR5 BF02434883_CR4 R. D. Morris (BF02434883_CR8) 1995; 103 J. R. Meier (BF02434883_CR7) 1988; 196 V. S. Zhurkov (BF02434883_CR2) 1993; 1-3 M. Koivusalo (BF02434883_CR6) 1997; 12 |
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| Snippet | Cyclohexene exhibits no mutagenic effect in the Ames test. Products of its transformation (chlorination) produced a mutagenic effect in the Ames test on TA 100... |
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| SubjectTerms | Animals Biotransformation Bone Marrow Cells - cytology Bone Marrow Cells - drug effects Cells, Cultured Chlorine - metabolism Colon - cytology Colon - drug effects Colorectal cancer Cyclohexanes - administration & dosage Cyclohexanes - chemistry Cyclohexanes - metabolism Cyclohexanes - toxicity Cyclohexenes Epithelial Cells - cytology Epithelial Cells - drug effects Liver - chemistry Liver - drug effects Liver - metabolism Male Mice Micronucleus Tests Mutagenicity Tests Mutation Rats Rats, Wistar Rodents Surface water Urinary Bladder - cytology Urinary Bladder - drug effects |
| Title | Mutagenic activity of cyclohexene and products of its chlorination |
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