Demonstration of X chromatin in drumstick-like nuclear appendages of leukocytes by in situ hybridization on blood smears

An X chromosome specific nucleic acid probe was used to study the positions of the X chromosomes in leukocyte nuclei by in situ hybridization to smears of peripheral blood. This autoradiographic approach allowed the first direct demonstration of the presence of X chromosomal material in the drumstic...

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Bibliographic Details
Published inHistochemistry (Berlin) Vol. 84; no. 4-6; p. 383
Main Authors Hochstenbach, P F, Scheres, J M, Hustinx, T W, Wieringa, B
Format Journal Article
LanguageEnglish
Published Germany 1986
Subjects
Cell Nucleus - analysis
Cell Nucleus - ultrastructure
Chromatin - analysis
Chromosomes, Human, 13-15
Humans
Neutrophils - analysis
Neutrophils - ultrastructure
Nucleic Acid Hybridization
Trisomy
X Chromosome - analysis
X Chromosome - ultrastructure
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Summary:An X chromosome specific nucleic acid probe was used to study the positions of the X chromosomes in leukocyte nuclei by in situ hybridization to smears of peripheral blood. This autoradiographic approach allowed the first direct demonstration of the presence of X chromosomal material in the drumstick-like structures of female polymorphonuclear leukocytes.
ISSN:0301-5564
DOI:10.1007/BF00482967