Detection of Oral Testosterone Undecanoate Administration in UGT2B17 del/del and del/ins Individuals. Part I: Urinary Steroid Profile and IRMS Markers

• Published in: Drug testing and analysis Vol. 17; no. 8; p. 1394
• Main Authors: Coll, Sergi, Shiomura, Sho, Alechaga, Élida, Bressan, Claudia, Monfort, Núria, Ventura, Rosa, Okano, Masato
• Format: Journal Article
• Language: English
• Published: England 01.08.2025
• Subjects: Administration, Oral; Adult; Anabolic Agents - administration & dosage; Anabolic Agents - urine; Asian People - genetics; Biomarkers - urine; Doping in Sports; Epitestosterone - urine; Female; Gene Deletion; Genotype; Glucuronosyltransferase - genetics; Humans; Male; Mass Spectrometry - methods; Minor Histocompatibility Antigens - genetics; Steroids - urine; Substance Abuse Detection - methods; Testosterone - administration & dosage; Testosterone - analogs & derivatives; Testosterone - urine; Young Adult; doping; urinary steroid profile; IRMS; ABP

The detection of endogenous anabolic androgenic steroids misuse in Asian population using the Steroidal Module of the Athlete Biological Passport (ABP) is a challenge due to the high prevalence of UGT2B17 gene deletion polymorphism and low levels of testosterone (T) glucuronide. In this study, the c...