Simvastatin Effects on Skeletal Muscle

• Published in: Journal of the American College of Cardiology Vol. 61; no. 1; pp. 44 - 53
• Main Authors: Larsen, Steen, Stride, Nis, Hey-Mogensen, Martin, Hansen, Christina N., Bang, Lia E., Bundgaard, Henning, Nielsen, Lars B., Helge, Jørn W., Dela, Flemming
• Format: Journal Article
• Language: English
• Published: New York Elsevier Inc 08.01.2013; Elsevier Limited
• Subjects: Cardiology; Cardiovascular; Cardiovascular disease; Cholesterol; Clinical trials; Colleges & universities; Diabetes; Drug therapy; Exercise; Glucose; glucose intolerance; Heart; Heart rate; Insulin; Kinases; mitochondrial function; Muscle pain; Musculoskeletal system; Q10 protein content; Rodents; simvastatin; Statins; mitochondrial function; glucose intolerance; simvastatin; CK; OXPHOS; HAD; ADP; CS; Q10; Q10 protein content; ROS; VDAC; OGTT; C50; Vo2MAX; oral glucose tolerance test; C 50; substrate sensitivity; coenzyme Q 10; citrate synthase; adenosine diphosphate; reactive oxygen species; creatine kinase; V o 2MAX; maximal oxygen uptake; Q 10; oxidative phosphorylation; voltage-dependent anion channel; beta-hydroxyacyl-CoA dehydrogenase

Glucose tolerance and skeletal muscle coenzyme Q10 (Q10) content, mitochondrial density, and mitochondrial oxidative phosphorylation (OXPHOS) capacity were measured in simvastatin-treated patients (n = 10) and in well-matched control subjects (n = 9). A prevalent side effect of statin therapy is mus...