Features of Microbiota in Newborns in Critical Condition at Admission to the Intensive Care Unit of a Specialized Hospital

• Published in: Vestnik anesteziologii i reanimatologii Vol. 19; no. 2; pp. 56 - 63
• Main Authors: Aleksandrovich, Yu. S., Ivanov, D. O., Pavlovskaya, E. Yu, Pshenisnov, K. V., Savicheva, A. M., Shalepo, K. V., Akimenko, T. I., Zemlyanoy, D. A.
• Format: Journal Article
• Language: English; Russian
• Published: New Terra Publishing House 07.05.2022
• Subjects: антибактериальная терапия; инфекции неонатального периода; критическое состояние; новорожденные; отделение интенсивной терапии новорожденных
• ISSN: 2078-5658; 2541-8653
• DOI: 10.21292/2078-5658-2022-19-2-56-63

Clarification of etiology and identification of infectious agents in critically ill newborns is a very urgent problem of neonatal resuscitation. The objective . To study the characteristics of microbiota in critically ill newborns at admission to the intensive care unit (ICU) of a specialized hospital. Subjects and Methods . 165 critically ill newborns were examined, and bacteriological tests of blood, feces, and saliva were performed. Results . Positive culture results were obtained in 40 (24%) patients. The most frequent causative agent was S. epidermidis (47.5%). The detection rate of E. faecalis amounted to 15%, S. haemolyticus ‒ 15%, C. albicans – 12.5%, and K. pneumoniae ‒ 10%. Microorganisms were isolated from feces in 70% of cases, from the oral cavity in 62.5%, and from blood in 12.5%. E. faecalis was equally frequent at all three sites (5%). Conclusion . In 76% of patients, no neonatal infectious agent was isolated at admission to ICU of a specialized hospital that is most likely associated with the early administration of antibacterial drugs in the first hours of life of the newborn.