Extracellular Domain of Pemphigus Vulgaris Antigen (Desmoglein 3) Mediates Weak Homophilic Adhesion

• Published in: Journal of investigative dermatology Vol. 103; no. 4; pp. 609 - 615
• Main Authors: Amagai, Masayuki, Kàrpàti, Sarolta, Klaus-Kovtun, Vera, Udey, Mark C, Stanley, John R
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.1994
• Subjects: Animals; autoimmune; cadherin; Cadherins - chemistry; catenin; Cell Adhesion; Chimera - genetics; Cytoplasm - chemistry; Desmoglein 3; desmosome; DNA, Complementary - analysis; L Cells (Cell Line) - immunology; L Cells (Cell Line) - physiology; Mice; Pemphigus - immunology; Transfection; desmosome; cadherin; autoimmune; catenin

Pemphigus vulgaris antigen is in the cadherin supergene family. We hypothesized that the extracellular domain of pemphigus vulgaris antigen might mediate homophilic cell adhesion because 1) the originally described cadherins (e.g., E-cadherin) mediate this type of adhesion, 2) pemphigus vulgaris ant...